Mary Wilson
Well-known member
Early Release / September 13, 2022 / 71
http://dx.doi.org/10.15585/mmwr.mm7138e1
Daniel M. Pastula, MD[SUP]1,[/SUP]*; Matthew J. Copeland, DO[SUP]2,[/SUP]*; Markus C. Hannan, MD[SUP]3[/SUP]; Samuel Rapaka, DO[SUP]2[/SUP]; Takashi Kitani, MD[SUP]4[/SUP]; Elizabeth Kleiner, MD[SUP]3[/SUP]; Adrienne Showler, MD[SUP]2[/SUP]; Cindy Yuen, DO[SUP]3[/SUP]; Elizabeth M. Ferriman[SUP]3[/SUP]; Jennifer House, DVM[SUP]5[/SUP]; Shannon O’Brien, MD[SUP]5[/SUP]; Alexis Burakoff, MD[SUP]5[/SUP]; Bhavik Gupta, DO[SUP]6[/SUP]; Kelli M. Money, MD, PhD[SUP]1[/SUP]; Elizabeth Matthews, MD[SUP]1[/SUP]; J. David Beckham, MD[SUP]1[/SUP]; Lakshmi Chauhan, MD[SUP]1[/SUP]; Amanda L. Piquet, MD[SUP]1[/SUP]; Rebecca N. Kumar, MD[SUP]2[/SUP]; Carlo S. Tornatore, MD[SUP]4[/SUP]; Kia Padgett, MPH[SUP]7[/SUP]; Kevin O’Laughlin, MD[SUP]7[/SUP]; Anil T. Mangla, PhD[SUP]8[/SUP]; Princy N. Kumar, MD[SUP]2[/SUP]; Kenneth L. Tyler, MD[SUP]1[/SUP]; Siobhán M. O’Connor, MD[SUP]7[/SUP]
Summary
What is already known about this topic?
Monkeypox virus (MPXV) typically causes a febrile illness with lymphadenopathy and a diffuse vesiculopustular rash; neurologic complications are rare. The current monkeypox outbreak differs clinically and epidemiologically from previous outbreaks, and little is known about potential associated neurologic complications.
What is added by this report?
Two U.S. cases of encephalomyelitis associated with acute MPXV infection were identified during summer 2022. Whether the underlying pathophysiology resulted from direct viral neuroinvasion or a parainfectious autoimmune process is currently unknown.
What are the implications for public health practice?
Suspected cases of neurologic complications of monkeypox should be reported to state, tribal, local, or territorial health departments to improve understanding of the range of clinical manifestations of MPXV infections during the current outbreak and treatment options.
... Details of two cases of encephalomyelitis associated with monkeypox in previously healthy young gay men in Colorado and DC are presented in this report. The University of Colorado and Georgetown University determined that this report was not subject to human subjects review because it includes only information obtained for purposes of patient clinical care and public health outbreak response. This activity was also reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.[SUP]†
https://www.cdc.gov/mmwr/volumes/71/wr/mm7138e1.htm#suggestedcitation[/SUP]
http://dx.doi.org/10.15585/mmwr.mm7138e1
Daniel M. Pastula, MD[SUP]1,[/SUP]*; Matthew J. Copeland, DO[SUP]2,[/SUP]*; Markus C. Hannan, MD[SUP]3[/SUP]; Samuel Rapaka, DO[SUP]2[/SUP]; Takashi Kitani, MD[SUP]4[/SUP]; Elizabeth Kleiner, MD[SUP]3[/SUP]; Adrienne Showler, MD[SUP]2[/SUP]; Cindy Yuen, DO[SUP]3[/SUP]; Elizabeth M. Ferriman[SUP]3[/SUP]; Jennifer House, DVM[SUP]5[/SUP]; Shannon O’Brien, MD[SUP]5[/SUP]; Alexis Burakoff, MD[SUP]5[/SUP]; Bhavik Gupta, DO[SUP]6[/SUP]; Kelli M. Money, MD, PhD[SUP]1[/SUP]; Elizabeth Matthews, MD[SUP]1[/SUP]; J. David Beckham, MD[SUP]1[/SUP]; Lakshmi Chauhan, MD[SUP]1[/SUP]; Amanda L. Piquet, MD[SUP]1[/SUP]; Rebecca N. Kumar, MD[SUP]2[/SUP]; Carlo S. Tornatore, MD[SUP]4[/SUP]; Kia Padgett, MPH[SUP]7[/SUP]; Kevin O’Laughlin, MD[SUP]7[/SUP]; Anil T. Mangla, PhD[SUP]8[/SUP]; Princy N. Kumar, MD[SUP]2[/SUP]; Kenneth L. Tyler, MD[SUP]1[/SUP]; Siobhán M. O’Connor, MD[SUP]7[/SUP]
Summary
What is already known about this topic?
Monkeypox virus (MPXV) typically causes a febrile illness with lymphadenopathy and a diffuse vesiculopustular rash; neurologic complications are rare. The current monkeypox outbreak differs clinically and epidemiologically from previous outbreaks, and little is known about potential associated neurologic complications.
What is added by this report?
Two U.S. cases of encephalomyelitis associated with acute MPXV infection were identified during summer 2022. Whether the underlying pathophysiology resulted from direct viral neuroinvasion or a parainfectious autoimmune process is currently unknown.
What are the implications for public health practice?
Suspected cases of neurologic complications of monkeypox should be reported to state, tribal, local, or territorial health departments to improve understanding of the range of clinical manifestations of MPXV infections during the current outbreak and treatment options.
... Details of two cases of encephalomyelitis associated with monkeypox in previously healthy young gay men in Colorado and DC are presented in this report. The University of Colorado and Georgetown University determined that this report was not subject to human subjects review because it includes only information obtained for purposes of patient clinical care and public health outbreak response. This activity was also reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.[SUP]†
https://www.cdc.gov/mmwr/volumes/71/wr/mm7138e1.htm#suggestedcitation[/SUP]