tetano
Editor, Senior Moderator
Cardiovasc Diagn Ther
. 2020 Oct;10(5):1303-1312.
doi: 10.21037/cdt-20-607.
Acute cardiac injury in adult hospitalized COVID-19 patients in Zhuhai, China
Lizi Jin[SUP] 1 [/SUP], Wenyi Tang[SUP] 1 [/SUP], Lizheng Song[SUP] 1 [/SUP], Liyun Luo[SUP] 1 [/SUP], Zhijuan Zhou[SUP] 1 [/SUP], Xiuwu Fan[SUP] 1 [/SUP], Jinyou Zhang[SUP] 1 [/SUP], Niujian Wu[SUP] 1 [/SUP], Kan Liu[SUP] 2 [/SUP], Jian Chen[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) has already became a public health emergency of international concern. COVID-19 related cardiac injury remains largely unclear.
Methods: We retrospectively analyzed demographic, clinical, laboratory and cardiovascular imaging data of all consecutively admitted adult COVID-19 patients in Zhuhai, China from January 17th, 2020 to February 18th, 2020.
Results: A total of 93 patients were included in the study. Acute cardiac injury was found in 9 (9.7%) COVID-19 patients with median level of hypersensitive cardiac troponin I (hs-cTnI) to be 0.085 ?g/L (IQR 0.027-0.560 ?g/L). Compared with patients without cardiac injury, the median age of patients with cardiac injury was significantly older (65.0 vs. 44.0, P<0.05), hypertension was significantly more common (44.4% vs. 14.3%, P<0.05), and the proportion of severe-critical cases were greater (77.8% vs. 17.9%, P<0.05). Patients with cardiac injury were more likely have elevation of N-terminal proBNP (NT-proBNP) in comparison (66.7% vs. 10.0%, P<0.05). There was no significant difference in echocardiographic parameters between patients with and without cardiac injury. Multivariable logistic regression analysis indicated that older age (OR: 1.093, 95% CI: 1.011-1.182) and increased NT-proBNP (OR: 10.979, 95% CI: 2.024-59.555) were independent risk factors for cardiac injury. Cardiac magnetic resonance (CMR) imaging performed on three patients at around one month after they underwent significant hs-cTnI elevation showed that they had underlying cardiovascular comorbidities.
Conclusions: Acute cardiac injury was seen in the minority of hospitalized COVID-19 patients in Zhuhai, China. Older age and increased NT-proBNP were associated with acute cardiac injury.
. 2020 Oct;10(5):1303-1312.
doi: 10.21037/cdt-20-607.
Acute cardiac injury in adult hospitalized COVID-19 patients in Zhuhai, China
Lizi Jin[SUP] 1 [/SUP], Wenyi Tang[SUP] 1 [/SUP], Lizheng Song[SUP] 1 [/SUP], Liyun Luo[SUP] 1 [/SUP], Zhijuan Zhou[SUP] 1 [/SUP], Xiuwu Fan[SUP] 1 [/SUP], Jinyou Zhang[SUP] 1 [/SUP], Niujian Wu[SUP] 1 [/SUP], Kan Liu[SUP] 2 [/SUP], Jian Chen[SUP] 1 [/SUP]
Affiliations
- PMID: 33224754
- PMCID: PMC7666934
- DOI: 10.21037/cdt-20-607
Abstract
Background: Coronavirus disease 2019 (COVID-19) has already became a public health emergency of international concern. COVID-19 related cardiac injury remains largely unclear.
Methods: We retrospectively analyzed demographic, clinical, laboratory and cardiovascular imaging data of all consecutively admitted adult COVID-19 patients in Zhuhai, China from January 17th, 2020 to February 18th, 2020.
Results: A total of 93 patients were included in the study. Acute cardiac injury was found in 9 (9.7%) COVID-19 patients with median level of hypersensitive cardiac troponin I (hs-cTnI) to be 0.085 ?g/L (IQR 0.027-0.560 ?g/L). Compared with patients without cardiac injury, the median age of patients with cardiac injury was significantly older (65.0 vs. 44.0, P<0.05), hypertension was significantly more common (44.4% vs. 14.3%, P<0.05), and the proportion of severe-critical cases were greater (77.8% vs. 17.9%, P<0.05). Patients with cardiac injury were more likely have elevation of N-terminal proBNP (NT-proBNP) in comparison (66.7% vs. 10.0%, P<0.05). There was no significant difference in echocardiographic parameters between patients with and without cardiac injury. Multivariable logistic regression analysis indicated that older age (OR: 1.093, 95% CI: 1.011-1.182) and increased NT-proBNP (OR: 10.979, 95% CI: 2.024-59.555) were independent risk factors for cardiac injury. Cardiac magnetic resonance (CMR) imaging performed on three patients at around one month after they underwent significant hs-cTnI elevation showed that they had underlying cardiovascular comorbidities.
Conclusions: Acute cardiac injury was seen in the minority of hospitalized COVID-19 patients in Zhuhai, China. Older age and increased NT-proBNP were associated with acute cardiac injury.