Commonground
Senior Moderator
Excerpts - bolding is mine
September 2, 2024
On 20 August 2024, the World Health Organization (WHO) was notified by the country’s International Health Regulations (IHR) National Focal Point (NFP) of a laboratory-confirmed case of human infection with avian influenza A(H5N1) virus (clade 2.3.2.1c) in a 15-year-old child in the Kingdom of Cambodia. This case is one of 10 human cases of influenza A(H5N1) infection reported in Cambodia in 2024. From 2003 to the present, 72 cases of human infection with influenza A(H5N1), including 43 deaths (case fatality ratio [CFR] of 59.7%), have been reported in the country. According to the IHR (2005), a human infection caused by a novel influenza A virus subtype is an event that has the potential for high public health impact and must be notified to the WHO. Based on currently available information, WHO assesses the current risk to the general population posed by this virus as low.
-snip-
Description of the situation:
...Swab specimens collected on 17 August arrived at the National Institute of Public Health of Cambodia on 19 August and tested positive for influenza A(H5N1) by quantitative reverse transcription polymerase chain reaction (RT-qPCR) on 20 August. The results were confirmed by the Institut Pasteur du Cambodge (IPC) the same day. The sample was successfully sequenced, and phylogenetic analysis of the haemagglutinin (HA) gene showed the virus to be H5 clade 2.3.2.1c, similar to the viruses circulating in Cambodia and Southeast Asia since 2013-2014. However, its internal genes belong to H5 clade 2.3.4.4b viruses. This novel reassortant influenza A(H5N1) virus has been detected in human cases reported in Cambodia since late 2023....
https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON533
September 2, 2024
On 20 August 2024, the World Health Organization (WHO) was notified by the country’s International Health Regulations (IHR) National Focal Point (NFP) of a laboratory-confirmed case of human infection with avian influenza A(H5N1) virus (clade 2.3.2.1c) in a 15-year-old child in the Kingdom of Cambodia. This case is one of 10 human cases of influenza A(H5N1) infection reported in Cambodia in 2024. From 2003 to the present, 72 cases of human infection with influenza A(H5N1), including 43 deaths (case fatality ratio [CFR] of 59.7%), have been reported in the country. According to the IHR (2005), a human infection caused by a novel influenza A virus subtype is an event that has the potential for high public health impact and must be notified to the WHO. Based on currently available information, WHO assesses the current risk to the general population posed by this virus as low.
-snip-
Description of the situation:
...Swab specimens collected on 17 August arrived at the National Institute of Public Health of Cambodia on 19 August and tested positive for influenza A(H5N1) by quantitative reverse transcription polymerase chain reaction (RT-qPCR) on 20 August. The results were confirmed by the Institut Pasteur du Cambodge (IPC) the same day. The sample was successfully sequenced, and phylogenetic analysis of the haemagglutinin (HA) gene showed the virus to be H5 clade 2.3.2.1c, similar to the viruses circulating in Cambodia and Southeast Asia since 2013-2014. However, its internal genes belong to H5 clade 2.3.4.4b viruses. This novel reassortant influenza A(H5N1) virus has been detected in human cases reported in Cambodia since late 2023....
https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON533