tetano
Editor, Senior Moderator
Braz J Med Biol Res
. 2022 Feb 16;55:e11711.
doi: 10.1590/1414-431X2021e11711. eCollection 2022.
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age
J Fabião[SUP] 1 [/SUP], B Sassi[SUP] 1 [/SUP], E F Pedrollo[SUP] 2 [/SUP], F Gerchman[SUP] 2 [/SUP], C K Kramer[SUP] 3 [/SUP], C B Leitão[SUP] 2 [/SUP], L C Pinto[SUP] 1 2 [/SUP]
Affiliations
Abstract
We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I2 63%, P for heterogeneity <0.01) compared to women. Age was not a significant covariate in meta-analysis heterogeneity (P=0.393) or subgroup analysis. For disease severity, being male was associated with a relative risk of 1.29 (95%CI: 1.19 to 1.40; I2 48%, P for heterogeneity <0.01) compared to the relative risk of women. Again, age did not influence the outcomes of the meta-regression (P=0.914) or subgroup analysis. Men had a higher risk of COVID-19 mortality and severity regardless of age, decreasing the odds of hormonal influences in the described outcomes.
. 2022 Feb 16;55:e11711.
doi: 10.1590/1414-431X2021e11711. eCollection 2022.
Why do men have worse COVID-19-related outcomes? A systematic review and meta-analysis with sex adjusted for age
J Fabião[SUP] 1 [/SUP], B Sassi[SUP] 1 [/SUP], E F Pedrollo[SUP] 2 [/SUP], F Gerchman[SUP] 2 [/SUP], C K Kramer[SUP] 3 [/SUP], C B Leitão[SUP] 2 [/SUP], L C Pinto[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35195196
- DOI: 10.1590/1414-431X2021e11711
Abstract
We aimed to study the mechanism behind worse coronavirus disease-19 (COVID-19) outcomes in men and whether the differences between sexes regarding mortality as well as disease severity are influenced by sex hormones. To do so, we used age as a covariate in the meta-regression and subgroup analyses. This was a systematic search and meta-analysis of observational cohorts reporting COVID-19 outcomes. The PubMed (Medline) and Cochrane Library databases were searched. The primary outcome was COVID-19-associated mortality and the secondary outcome was COVID-19 severity. The study was registered at PROSPERO: 42020182924. For mortality, men had a relative risk of 1.36 (95%CI: 1.17 to 1.59; I2 63%, P for heterogeneity <0.01) compared to women. Age was not a significant covariate in meta-analysis heterogeneity (P=0.393) or subgroup analysis. For disease severity, being male was associated with a relative risk of 1.29 (95%CI: 1.19 to 1.40; I2 48%, P for heterogeneity <0.01) compared to the relative risk of women. Again, age did not influence the outcomes of the meta-regression (P=0.914) or subgroup analysis. Men had a higher risk of COVID-19 mortality and severity regardless of age, decreasing the odds of hormonal influences in the described outcomes.