tetano
Editor, Senior Moderator
Brain Dev
. 2020 Oct 13;S0387-7604(20)30280-1.
doi: 10.1016/j.braindev.2020.10.002. Online ahead of print.
Reversible splenial lesion syndrome associated with SARS-CoV-2 infection in two children
Gonca Bektaş[SUP] 1 [/SUP], Nihal Ak?ay[SUP] 2 [/SUP], K?bra Boydağ[SUP] 2 [/SUP], Esra Şevketoğlu[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Reversible splenial lesion syndrome (RESLES) is characterized by a temporary lesion in the splenium of the corpus callosum, emerging related to encephalitis, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Among RESLES, mild encephalitis/encephalopathy with reversible splenial lesion (MERS) has been defined as a distinct clinicoradiologic syndrome associated with viral infections.
Case presentation: We report two children with multisystem inflammatory syndrome-children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed RESLES during the disease course. Encephalopathy was the main central nervous system symptom. Both of the children showed a rapid recovery, and brain magnetic resonance imaging revealed complete resolution of the splenial lesion within 1 week.
Conclusion: The complete resolution of the splenial lesion and rapid recovery from encephalopathy in RESLES associated with SARS CoV-2 were similar to observed in MERS.
Keywords: Child; Coronavirus; Corpus callosum; Encephalitis.
. 2020 Oct 13;S0387-7604(20)30280-1.
doi: 10.1016/j.braindev.2020.10.002. Online ahead of print.
Reversible splenial lesion syndrome associated with SARS-CoV-2 infection in two children
Gonca Bektaş[SUP] 1 [/SUP], Nihal Ak?ay[SUP] 2 [/SUP], K?bra Boydağ[SUP] 2 [/SUP], Esra Şevketoğlu[SUP] 2 [/SUP]
Affiliations
- PMID: 33082059
- DOI: 10.1016/j.braindev.2020.10.002
Abstract
Background: Reversible splenial lesion syndrome (RESLES) is characterized by a temporary lesion in the splenium of the corpus callosum, emerging related to encephalitis, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Among RESLES, mild encephalitis/encephalopathy with reversible splenial lesion (MERS) has been defined as a distinct clinicoradiologic syndrome associated with viral infections.
Case presentation: We report two children with multisystem inflammatory syndrome-children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed RESLES during the disease course. Encephalopathy was the main central nervous system symptom. Both of the children showed a rapid recovery, and brain magnetic resonance imaging revealed complete resolution of the splenial lesion within 1 week.
Conclusion: The complete resolution of the splenial lesion and rapid recovery from encephalopathy in RESLES associated with SARS CoV-2 were similar to observed in MERS.
Keywords: Child; Coronavirus; Corpus callosum; Encephalitis.