tetano
Editor, Senior Moderator
Br J Haematol
. 2020 Jul 17.
doi: 10.1111/bjh.17034. Online ahead of print.
Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients
Silvia Bellesi[SUP] 1 [/SUP], Elisabetta Metafuni[SUP] 1 [/SUP], Stefan Hohaus[SUP] 1 2 [/SUP], Elena Maiolo[SUP] 1 [/SUP], Federica Marchionni[SUP] 1 [/SUP], Simone D'Innocenzo[SUP] 1 [/SUP], Marilena La Sorda[SUP] 3 [/SUP], Manuela Ferraironi[SUP] 3 [/SUP], Francesco Ramundo[SUP] 2 [/SUP], Massimo Fantoni[SUP] 3 4 [/SUP], Rita Murri[SUP] 3 4 [/SUP], Antonella Cingolani[SUP] 3 4 [/SUP], Simona Sica[SUP] 1 2 [/SUP], Antonio Gasbarrini[SUP] 5 [/SUP], Maurizio Sanguinetti[SUP] 3 6 [/SUP], Patrizia Chiusolo[SUP] 1 2 [/SUP], Valerio De Stefano[SUP] 1 2 [/SUP]
Affiliations
Abstract
A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the Coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of Naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
Keywords: CD95 (Fas); COVID-19; PD-1; apoptosis; exhaustion.
. 2020 Jul 17.
doi: 10.1111/bjh.17034. Online ahead of print.
Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients
Silvia Bellesi[SUP] 1 [/SUP], Elisabetta Metafuni[SUP] 1 [/SUP], Stefan Hohaus[SUP] 1 2 [/SUP], Elena Maiolo[SUP] 1 [/SUP], Federica Marchionni[SUP] 1 [/SUP], Simone D'Innocenzo[SUP] 1 [/SUP], Marilena La Sorda[SUP] 3 [/SUP], Manuela Ferraironi[SUP] 3 [/SUP], Francesco Ramundo[SUP] 2 [/SUP], Massimo Fantoni[SUP] 3 4 [/SUP], Rita Murri[SUP] 3 4 [/SUP], Antonella Cingolani[SUP] 3 4 [/SUP], Simona Sica[SUP] 1 2 [/SUP], Antonio Gasbarrini[SUP] 5 [/SUP], Maurizio Sanguinetti[SUP] 3 6 [/SUP], Patrizia Chiusolo[SUP] 1 2 [/SUP], Valerio De Stefano[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32679621
- DOI: 10.1111/bjh.17034
Abstract
A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the Coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of Naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
Keywords: CD95 (Fas); COVID-19; PD-1; apoptosis; exhaustion.