tetano
Editor, Senior Moderator
BMJ Open Respir Res
. 2024 Apr 24;11(1):e002234.
doi: 10.1136/bmjresp-2023-002234. Lung volume measurement using chest CT in COVID-19 patients: a cohort study in Japan
Shiro Otake[SUP] 1 [/SUP], Yusuke Shiraishi[SUP] 2 [/SUP], Shotaro Chubachi[SUP] 3 [/SUP], Naoya Tanabe[SUP] 2 [/SUP], Tomoki Maetani[SUP] 2 [/SUP], Takanori Asakura[SUP] 4 [/SUP], Ho Namkoong[SUP] 4 [/SUP], Takashi Shimada[SUP] 1 [/SUP], Shuhei Azekawa[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Mayuko Watase[SUP] 5 [/SUP], Hideki Terai[SUP] 1 [/SUP], Mamoru Sasaki[SUP] 6 [/SUP], Soichiro Ueda[SUP] 6 [/SUP], Yukari Kato[SUP] 7 [/SUP], Norihiro Harada[SUP] 7 [/SUP], Shoji Suzuki[SUP] 8 [/SUP], Shuichi Yoshida[SUP] 8 [/SUP], Hiroki Tateno[SUP] 8 [/SUP], Yoshitake Yamada[SUP] 9 [/SUP], Masahiro Jinzaki[SUP] 9 [/SUP], Toyohiro Hirai[SUP] 10 [/SUP], Yukinori Okada[SUP] 11 12 [/SUP], Ryuji Koike[SUP] 13 [/SUP], Makoto Ishii[SUP] 14 [/SUP], Naoki Hasegawa[SUP] 15 [/SUP], Akinori Kimura[SUP] 16 [/SUP], Seiya Imoto[SUP] 17 [/SUP], Satoru Miyano[SUP] 18 [/SUP], Seishi Ogawa[SUP] 19 20 [/SUP], Takanori Kanai[SUP] 21 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]
Affiliations
Objective: This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients.
Methods: This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLC[SUB]ct[/SUB] (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months.
Results: The incidence of critical outcomes was higher in the low TLC[SUB]ct[/SUB] (%pred) group than in the high TLC[SUB]ct[/SUB] (%pred) group (14.2% vs 3.3%, p<0.0001). Multivariable analysis of previously reported factors (age, sex, body mass index and comorbidities) demonstrated that CT-derived lung volume was significantly associated with critical outcomes. The low TLC[SUB]ct[/SUB] (%pred) group exhibited a higher incidence of bacterial infection, heart failure, thromboembolism, liver dysfunction and renal dysfunction than the high TLC[SUB]ct[/SUB] (%pred) group. TLC[SUB]ct[/SUB] (%pred) at 3 months was similarly divided into two groups at the median (71.8%). Among patients with follow-up CT scans, lung volumes showed a recovery trend from the time of admission to 3 months but remained lower in critical cases at 3 months.
Conclusion: Lower CT lung volume was associated with critical outcomes, posthospitalisation complications and slower improvement of clinical conditions in COVID-19 patients.
Keywords: COVID-19; imaging/CT MRI etc.
. 2024 Apr 24;11(1):e002234.
doi: 10.1136/bmjresp-2023-002234. Lung volume measurement using chest CT in COVID-19 patients: a cohort study in Japan
Shiro Otake[SUP] 1 [/SUP], Yusuke Shiraishi[SUP] 2 [/SUP], Shotaro Chubachi[SUP] 3 [/SUP], Naoya Tanabe[SUP] 2 [/SUP], Tomoki Maetani[SUP] 2 [/SUP], Takanori Asakura[SUP] 4 [/SUP], Ho Namkoong[SUP] 4 [/SUP], Takashi Shimada[SUP] 1 [/SUP], Shuhei Azekawa[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Takahiro Fukushima[SUP] 1 [/SUP], Mayuko Watase[SUP] 5 [/SUP], Hideki Terai[SUP] 1 [/SUP], Mamoru Sasaki[SUP] 6 [/SUP], Soichiro Ueda[SUP] 6 [/SUP], Yukari Kato[SUP] 7 [/SUP], Norihiro Harada[SUP] 7 [/SUP], Shoji Suzuki[SUP] 8 [/SUP], Shuichi Yoshida[SUP] 8 [/SUP], Hiroki Tateno[SUP] 8 [/SUP], Yoshitake Yamada[SUP] 9 [/SUP], Masahiro Jinzaki[SUP] 9 [/SUP], Toyohiro Hirai[SUP] 10 [/SUP], Yukinori Okada[SUP] 11 12 [/SUP], Ryuji Koike[SUP] 13 [/SUP], Makoto Ishii[SUP] 14 [/SUP], Naoki Hasegawa[SUP] 15 [/SUP], Akinori Kimura[SUP] 16 [/SUP], Seiya Imoto[SUP] 17 [/SUP], Satoru Miyano[SUP] 18 [/SUP], Seishi Ogawa[SUP] 19 20 [/SUP], Takanori Kanai[SUP] 21 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP]
Affiliations
- PMID: 38663888
- DOI: 10.1136/bmjresp-2023-002234
Objective: This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients.
Methods: This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLC[SUB]ct[/SUB] (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months.
Results: The incidence of critical outcomes was higher in the low TLC[SUB]ct[/SUB] (%pred) group than in the high TLC[SUB]ct[/SUB] (%pred) group (14.2% vs 3.3%, p<0.0001). Multivariable analysis of previously reported factors (age, sex, body mass index and comorbidities) demonstrated that CT-derived lung volume was significantly associated with critical outcomes. The low TLC[SUB]ct[/SUB] (%pred) group exhibited a higher incidence of bacterial infection, heart failure, thromboembolism, liver dysfunction and renal dysfunction than the high TLC[SUB]ct[/SUB] (%pred) group. TLC[SUB]ct[/SUB] (%pred) at 3 months was similarly divided into two groups at the median (71.8%). Among patients with follow-up CT scans, lung volumes showed a recovery trend from the time of admission to 3 months but remained lower in critical cases at 3 months.
Conclusion: Lower CT lung volume was associated with critical outcomes, posthospitalisation complications and slower improvement of clinical conditions in COVID-19 patients.
Keywords: COVID-19; imaging/CT MRI etc.