tetano
Editor, Senior Moderator
BMJ Open Respir Res
. 2025 Jun 8;12(1):e002789.
doi: 10.1136/bmjresp-2024-002789. Long-term multidimensional patient-centred outcomes after hospitalisation for COVID-19: do not only focus on disease severity
Martine Bek[SUP] 1 [/SUP], Yasemin Türk[SUP] 2 [/SUP], Matthijs L Janssen[SUP] 3 4 5 [/SUP], Gemma Weijsters[SUP] 2 [/SUP], Julia C Berentschot[SUP] 5 [/SUP], Rita J G van den Berg-Emons[SUP] 6 [/SUP], Majanka H Heijenbrok-Kal[SUP] 6 7 [/SUP], Gerard M Ribbers[SUP] 6 7 [/SUP], Joachim Aerts[SUP] 5 [/SUP], Wessel E J J Hanselaar[SUP] 2 [/SUP], Henrik Endeman[SUP] 4 [/SUP], Merel E Hellemons[SUP] 5 [/SUP], Evert-Jan Wils[SUP] 3 4 [/SUP]; CO-FLOW collaboration group; Dutch HFNO COVID-19 study group; On behalf of
Collaborators, Collaborators, Affiliations
Objectives: To investigate the association between COVID-19 disease severity during hospitalisation for COVID-19 and long-term multidimensional patient-centred outcomes up to 12 months post-hospitalisation. The secondary objective was to identify other risk factors for these long-term outcomes.
Methods: In this multicentre prospective cohort study, we categorised COVID-19 disease severity using the maximal level of respiratory support as proxy into (1) conventional oxygen therapy (COT), (2) high-flow nasal oxygen (HFNO) and (3) invasive mechanical ventilation (IMV). The primary outcome health-related quality of life (HRQoL), and the secondary outcomes self-reported symptoms and recovery were collected at 6 and 12 months post-hospitalisation.
Results: Data from 777 patients were analysed, with 226 (29%) receiving COT, 273 (35%) HFNO and 278 (36%) IMV. Patients reported impaired HRQoL, persistence of symptoms and poor recovery. Multivariable generalised estimating equations analysis showed that COVID-19 disease severity was not associated with HRQoL and inconsistently with symptoms; the HFNO group reported poorer recovery. Overall, female sex, younger age and pulmonary history were independent risk factors for outcomes.
Conclusions: COVID-19 disease severity was associated with self-perceived recovery, but not with HRQoL and inconsistently with symptoms. Our findings suggest that age, sex and pulmonary history are more consistent risk factors for long-term multidimensional outcomes and offer better guidance for aftercare strategies.
Keywords: COVID-19; Critical Care; Patient Outcome Assessment; Respiratory Infection.
. 2025 Jun 8;12(1):e002789.
doi: 10.1136/bmjresp-2024-002789. Long-term multidimensional patient-centred outcomes after hospitalisation for COVID-19: do not only focus on disease severity
Martine Bek[SUP] 1 [/SUP], Yasemin Türk[SUP] 2 [/SUP], Matthijs L Janssen[SUP] 3 4 5 [/SUP], Gemma Weijsters[SUP] 2 [/SUP], Julia C Berentschot[SUP] 5 [/SUP], Rita J G van den Berg-Emons[SUP] 6 [/SUP], Majanka H Heijenbrok-Kal[SUP] 6 7 [/SUP], Gerard M Ribbers[SUP] 6 7 [/SUP], Joachim Aerts[SUP] 5 [/SUP], Wessel E J J Hanselaar[SUP] 2 [/SUP], Henrik Endeman[SUP] 4 [/SUP], Merel E Hellemons[SUP] 5 [/SUP], Evert-Jan Wils[SUP] 3 4 [/SUP]; CO-FLOW collaboration group; Dutch HFNO COVID-19 study group; On behalf of
Collaborators, Collaborators, Affiliations
- PMID: 40484638
- DOI: 10.1136/bmjresp-2024-002789
Objectives: To investigate the association between COVID-19 disease severity during hospitalisation for COVID-19 and long-term multidimensional patient-centred outcomes up to 12 months post-hospitalisation. The secondary objective was to identify other risk factors for these long-term outcomes.
Methods: In this multicentre prospective cohort study, we categorised COVID-19 disease severity using the maximal level of respiratory support as proxy into (1) conventional oxygen therapy (COT), (2) high-flow nasal oxygen (HFNO) and (3) invasive mechanical ventilation (IMV). The primary outcome health-related quality of life (HRQoL), and the secondary outcomes self-reported symptoms and recovery were collected at 6 and 12 months post-hospitalisation.
Results: Data from 777 patients were analysed, with 226 (29%) receiving COT, 273 (35%) HFNO and 278 (36%) IMV. Patients reported impaired HRQoL, persistence of symptoms and poor recovery. Multivariable generalised estimating equations analysis showed that COVID-19 disease severity was not associated with HRQoL and inconsistently with symptoms; the HFNO group reported poorer recovery. Overall, female sex, younger age and pulmonary history were independent risk factors for outcomes.
Conclusions: COVID-19 disease severity was associated with self-perceived recovery, but not with HRQoL and inconsistently with symptoms. Our findings suggest that age, sex and pulmonary history are more consistent risk factors for long-term multidimensional outcomes and offer better guidance for aftercare strategies.
Keywords: COVID-19; Critical Care; Patient Outcome Assessment; Respiratory Infection.