tetano
Editor, Senior Moderator
BMJ Case Rep
. 2021 May 26;14(5):e242921.
doi: 10.1136/bcr-2021-242921.
Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
Purva Sharma[SUP] 1 [/SUP], Kanishka Chakraborty[SUP] 2 [/SUP]
Affiliations
Abstract
COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hodgkin's lymphoma, who was diagnosed with COVID-19 infection prior to initiating chemotherapy. Two months after resolution of symptoms and testing negative for COVID-19, she presented with multiple acute thromboembolic complications of the infection, including bilateral jugular venous thrombosis, right atrial clot and arterial emboli in the brain resulting in cerebrovascular injury. These were thought to be delayed manifestations of the systemic coagulopathy secondary to infection. Also, some of these thromboembolic phenomena occurred while the patient was on anticoagulation, which emphasises the extensive hyperinflammatory state caused by the virus. This case highlights the importance of thromboprophylaxis especially in high-risk patients with this infection.
Keywords: COVID-19; haematology (incl blood transfusion); venous thromboembolism.
. 2021 May 26;14(5):e242921.
doi: 10.1136/bcr-2021-242921.
Delayed manifestation of extensive COVID-19-associated coagulopathy in high-risk patient
Purva Sharma[SUP] 1 [/SUP], Kanishka Chakraborty[SUP] 2 [/SUP]
Affiliations
- PMID: 34039554
- DOI: 10.1136/bcr-2021-242921
Abstract
COVID-19 is an infectious disease caused by the novel coronavirus. It presents as an acute respiratory illness, however, it also affects multiple other organ systems. One such unique manifestation is systemic coagulopathy involving arterial and venous systems. We present a 29-year-old woman with Hodgkin's lymphoma, who was diagnosed with COVID-19 infection prior to initiating chemotherapy. Two months after resolution of symptoms and testing negative for COVID-19, she presented with multiple acute thromboembolic complications of the infection, including bilateral jugular venous thrombosis, right atrial clot and arterial emboli in the brain resulting in cerebrovascular injury. These were thought to be delayed manifestations of the systemic coagulopathy secondary to infection. Also, some of these thromboembolic phenomena occurred while the patient was on anticoagulation, which emphasises the extensive hyperinflammatory state caused by the virus. This case highlights the importance of thromboprophylaxis especially in high-risk patients with this infection.
Keywords: COVID-19; haematology (incl blood transfusion); venous thromboembolism.