tetano
Editor, Senior Moderator
BMC Med Imaging
. 2022 Nov 29;22(1):209.
doi: 10.1186/s12880-022-00937-9.
Analysis of CT signs, radiomic features and clinical characteristics for delta variant COVID-19 patients with different vaccination status
Huanhuan Wei[SUP] #[/SUP][SUP] 1 [/SUP], Zehua Shao[SUP] #[/SUP][SUP] 2 [/SUP], Jianqing Tai[SUP] #[/SUP][SUP] 3 [/SUP], Fangfang Fu[SUP] #[/SUP][SUP] 4 [/SUP], Chuanjian Lv[SUP] #[/SUP][SUP] 4 [/SUP], Zhiping Guo[SUP] 3 [/SUP], Yaping Wu[SUP] 4 [/SUP], Lijuan Chen[SUP] 4 [/SUP], Yan Bai[SUP] 4 [/SUP], Qingxia Wu[SUP] 5 [/SUP], Xuan Yu[SUP] 4 [/SUP], Xinling Mu[SUP] 6 [/SUP], Fengmin Shao[SUP] 7 [/SUP], Meiyun Wang[SUP] 8 9 [/SUP]
Affiliations
Abstract
Objective: To explore the characteristics of peripheral blood, high resolution computed tomography (HRCT) imaging and the radiomics signature (RadScore) in patients infected with delta variant virus under different coronavirus disease (COVID-19) vaccination status.
Methods: 123 patients with delta variant virus infection collected from November 1, 2021 to March 1, 2022 were analyzed retrospectively. According to COVID-19 vaccination Status, they were divided into three groups: Unvaccinated group, partially vaccinated group and full vaccination group. The peripheral blood, chest HRCT manifestations and RadScore of each group were analyzed and compared.
Results: The mean lymphocyte count 1.22 ± 0.49 × 10^[SUP]9[/SUP]/L, CT score 7.29 ± 3.48, RadScore 0.75 ± 0.63 in the unvaccinated group; The mean lymphocyte count 1.55 ± 0.70 × 10^[SUP]9[/SUP]/L, CT score 5.27 ± 2.72, RadScore 1.03 ± 0.46 in the partially vaccinated group; The mean lymphocyte count 1.87 ± 0.70 × 10^9/L, CT score 3.59 ± 3.14, RadScore 1.23 ± 0.29 in the fully vaccinated group. There were significant differences in lymphocyte count, CT score and RadScore among the three groups (all p < 0.05); Compared with the other two groups, the lung lesions in the unvaccinated group were more involved in multiple lobes, of which 26 cases involved the whole lung.
Conclusions: Through the analysis of clinical features, pulmonary imaging features and radiomics, we confirmed the positive effect of COVID-19 vaccine on pulmonary inflammatory symptoms and lymphocyte count (immune system) during delta mutant infection.
Keywords: COVID-19 vaccine; Computed tomography; Radiomics.
. 2022 Nov 29;22(1):209.
doi: 10.1186/s12880-022-00937-9.
Analysis of CT signs, radiomic features and clinical characteristics for delta variant COVID-19 patients with different vaccination status
Huanhuan Wei[SUP] #[/SUP][SUP] 1 [/SUP], Zehua Shao[SUP] #[/SUP][SUP] 2 [/SUP], Jianqing Tai[SUP] #[/SUP][SUP] 3 [/SUP], Fangfang Fu[SUP] #[/SUP][SUP] 4 [/SUP], Chuanjian Lv[SUP] #[/SUP][SUP] 4 [/SUP], Zhiping Guo[SUP] 3 [/SUP], Yaping Wu[SUP] 4 [/SUP], Lijuan Chen[SUP] 4 [/SUP], Yan Bai[SUP] 4 [/SUP], Qingxia Wu[SUP] 5 [/SUP], Xuan Yu[SUP] 4 [/SUP], Xinling Mu[SUP] 6 [/SUP], Fengmin Shao[SUP] 7 [/SUP], Meiyun Wang[SUP] 8 9 [/SUP]
Affiliations
- PMID: 36447133
- DOI: 10.1186/s12880-022-00937-9
Abstract
Objective: To explore the characteristics of peripheral blood, high resolution computed tomography (HRCT) imaging and the radiomics signature (RadScore) in patients infected with delta variant virus under different coronavirus disease (COVID-19) vaccination status.
Methods: 123 patients with delta variant virus infection collected from November 1, 2021 to March 1, 2022 were analyzed retrospectively. According to COVID-19 vaccination Status, they were divided into three groups: Unvaccinated group, partially vaccinated group and full vaccination group. The peripheral blood, chest HRCT manifestations and RadScore of each group were analyzed and compared.
Results: The mean lymphocyte count 1.22 ± 0.49 × 10^[SUP]9[/SUP]/L, CT score 7.29 ± 3.48, RadScore 0.75 ± 0.63 in the unvaccinated group; The mean lymphocyte count 1.55 ± 0.70 × 10^[SUP]9[/SUP]/L, CT score 5.27 ± 2.72, RadScore 1.03 ± 0.46 in the partially vaccinated group; The mean lymphocyte count 1.87 ± 0.70 × 10^9/L, CT score 3.59 ± 3.14, RadScore 1.23 ± 0.29 in the fully vaccinated group. There were significant differences in lymphocyte count, CT score and RadScore among the three groups (all p < 0.05); Compared with the other two groups, the lung lesions in the unvaccinated group were more involved in multiple lobes, of which 26 cases involved the whole lung.
Conclusions: Through the analysis of clinical features, pulmonary imaging features and radiomics, we confirmed the positive effect of COVID-19 vaccine on pulmonary inflammatory symptoms and lymphocyte count (immune system) during delta mutant infection.
Keywords: COVID-19 vaccine; Computed tomography; Radiomics.