tetano
Editor, Senior Moderator
BMC Infect Dis
. 2023 Nov 3;23(1):757.
doi: 10.1186/s12879-023-08763-2. Symptomatic MERS-CoV infection reduces the risk of future COVID-19 disease; a retrospective cohort study
Aiman El-Saed[SUP] 1 2 3 [/SUP], Fatmah Othman[SUP] 3 4 [/SUP], Henry Baffoe-Bonnie[SUP] 1 [/SUP], Rawabi Almulhem[SUP] 1 [/SUP], Muayed Matalqah[SUP] 1 [/SUP], Latifah Alshammari[SUP] 5 [/SUP], Majid M Alshamrani[SUP] 6 7 8 [/SUP]
Affiliations
Background: The general human immune responses similarity against different coronaviruses may reflect some degree of cross-immunity, whereby exposure to one coronavirus may confer partial immunity to another. The aim was to determine whether previous MERS-CoV infection was associated with a lower risk of subsequent COVID-19 disease and its related outcomes.
Methods: We conducted a retrospective cohort study among all patients screened for MERS-CoV at a tertiary care hospital in Saudi Arabia between 2012 and early 2020. Both MERS-CoV positive and negative patients were followed up from early 2020 to September 2021 for developing COVID-19 infection confirmed by RT-PCR testing.
Results: A total of 397 participants followed for an average 15 months during COVID-19 pandemic (4.9 years from MERS-CoV infection). Of the 397 participants, 93 (23.4%) were positive for MERS-CoV at baseline; 61 (65.6%) of the positive cases were symptomatic. Out of 397, 48 (12.1%) participants developed COVID-19 by the end of the follow-up period. Cox regression analysis adjusted for age, gender, and major comorbidity showed a marginally significant lower risk of COVID-19 disease (hazard ratio = 0.533, p = 0.085) and hospital admission (hazard ratio = 0.411, p = 0.061) in patients with positive MERS-CoV. Additionally, the risk of COVID-19 disease was further reduced and became significant in patients with symptomatic MERS-CoV infection (hazard ratio = 0.324, p = 0.034) and hospital admission (hazard ratio = 0.317, p = 0.042).
Conclusions: The current findings may indicate a partial cross-immunity, where patients with symptomatic MERS-CoV have a lower risk of future COVID-19 infection and related hospitalization. The present results may need further examination nationally using immunity markers.
Keywords: COVID-19; Cross-immunity; Cross-protection; MERS-CoV; Saudi Arabia.
. 2023 Nov 3;23(1):757.
doi: 10.1186/s12879-023-08763-2. Symptomatic MERS-CoV infection reduces the risk of future COVID-19 disease; a retrospective cohort study
Aiman El-Saed[SUP] 1 2 3 [/SUP], Fatmah Othman[SUP] 3 4 [/SUP], Henry Baffoe-Bonnie[SUP] 1 [/SUP], Rawabi Almulhem[SUP] 1 [/SUP], Muayed Matalqah[SUP] 1 [/SUP], Latifah Alshammari[SUP] 5 [/SUP], Majid M Alshamrani[SUP] 6 7 8 [/SUP]
Affiliations
- PMID: 37924004
- DOI: 10.1186/s12879-023-08763-2
Background: The general human immune responses similarity against different coronaviruses may reflect some degree of cross-immunity, whereby exposure to one coronavirus may confer partial immunity to another. The aim was to determine whether previous MERS-CoV infection was associated with a lower risk of subsequent COVID-19 disease and its related outcomes.
Methods: We conducted a retrospective cohort study among all patients screened for MERS-CoV at a tertiary care hospital in Saudi Arabia between 2012 and early 2020. Both MERS-CoV positive and negative patients were followed up from early 2020 to September 2021 for developing COVID-19 infection confirmed by RT-PCR testing.
Results: A total of 397 participants followed for an average 15 months during COVID-19 pandemic (4.9 years from MERS-CoV infection). Of the 397 participants, 93 (23.4%) were positive for MERS-CoV at baseline; 61 (65.6%) of the positive cases were symptomatic. Out of 397, 48 (12.1%) participants developed COVID-19 by the end of the follow-up period. Cox regression analysis adjusted for age, gender, and major comorbidity showed a marginally significant lower risk of COVID-19 disease (hazard ratio = 0.533, p = 0.085) and hospital admission (hazard ratio = 0.411, p = 0.061) in patients with positive MERS-CoV. Additionally, the risk of COVID-19 disease was further reduced and became significant in patients with symptomatic MERS-CoV infection (hazard ratio = 0.324, p = 0.034) and hospital admission (hazard ratio = 0.317, p = 0.042).
Conclusions: The current findings may indicate a partial cross-immunity, where patients with symptomatic MERS-CoV have a lower risk of future COVID-19 infection and related hospitalization. The present results may need further examination nationally using immunity markers.
Keywords: COVID-19; Cross-immunity; Cross-protection; MERS-CoV; Saudi Arabia.