tetano
Editor, Senior Moderator
BMC Infect Dis
. 2020 Dec 11;20(1):953.
doi: 10.1186/s12879-020-05683-3.
Maximum chest CT score is associated with progression to severe illness in patients with COVID-19: a retrospective study from Wuhan, China
Jianwei Xiao[SUP] 1 [/SUP], Xiang Li[SUP] 1 [/SUP], Yuanliang Xie[SUP] 1 [/SUP], Zengfa Huang[SUP] 1 [/SUP], Yi Ding[SUP] 1 [/SUP], Shengchao Zhao[SUP] 1 [/SUP], Pei Yang[SUP] 1 [/SUP], Dan Du[SUP] 1 [/SUP], Bin Liu[SUP] 1 [/SUP], Xiang Wang[SUP] 2 [/SUP]
Affiliations
Abstract
Background: The Coronavirus Disease 2019 (COVID-19) pandemic is a world-wide health crisis. Limited information is available regarding which patients will experience more severe disease symptoms. We evaluated hospitalized patients who were initially diagnosed with moderate COVID-19 for clinical parameters and radiological feature that showed an association with progression to severe/critical symptoms.
Methods: This study, a retrospective single-center study at the Central Hospital of Wuhan, enrolled 243 patients with confirmed COVID-19 pneumonia. Forty of these patients progressed from moderate to severe/critical symptoms during follow up. Demographic, clinical, laboratory, and radiological data were extracted from electronic medical records and compared between moderate- and severe/critical-type symptoms. Univariable and multivariable logistic regressions were used to identify the risk factors associated with symptom progression.
Results: Patients with severe/critical symptoms were older (p < 0.001) and more often male (p = 0.046). A combination of chronic obstructive pulmonary disease (COPD) and high maximum chest computed tomography (CT) score was associated with disease progression. Maximum CT score (> 11) had the greatest predictive value for disease progression. The area under the receiver operating characteristic curve was 0.861 (95% confidence interval: 0.811-0.902).
Conclusions: Maximum CT score and COPD were associated with patient deterioration. Maximum CT score (> 11) was associated with severe illness.
Keywords: COPD; COVID-19; CT score; Chest CT; Multivariate regression; ROC.
. 2020 Dec 11;20(1):953.
doi: 10.1186/s12879-020-05683-3.
Maximum chest CT score is associated with progression to severe illness in patients with COVID-19: a retrospective study from Wuhan, China
Jianwei Xiao[SUP] 1 [/SUP], Xiang Li[SUP] 1 [/SUP], Yuanliang Xie[SUP] 1 [/SUP], Zengfa Huang[SUP] 1 [/SUP], Yi Ding[SUP] 1 [/SUP], Shengchao Zhao[SUP] 1 [/SUP], Pei Yang[SUP] 1 [/SUP], Dan Du[SUP] 1 [/SUP], Bin Liu[SUP] 1 [/SUP], Xiang Wang[SUP] 2 [/SUP]
Affiliations
- PMID: 33308183
- PMCID: PMC7729688
- DOI: 10.1186/s12879-020-05683-3
Abstract
Background: The Coronavirus Disease 2019 (COVID-19) pandemic is a world-wide health crisis. Limited information is available regarding which patients will experience more severe disease symptoms. We evaluated hospitalized patients who were initially diagnosed with moderate COVID-19 for clinical parameters and radiological feature that showed an association with progression to severe/critical symptoms.
Methods: This study, a retrospective single-center study at the Central Hospital of Wuhan, enrolled 243 patients with confirmed COVID-19 pneumonia. Forty of these patients progressed from moderate to severe/critical symptoms during follow up. Demographic, clinical, laboratory, and radiological data were extracted from electronic medical records and compared between moderate- and severe/critical-type symptoms. Univariable and multivariable logistic regressions were used to identify the risk factors associated with symptom progression.
Results: Patients with severe/critical symptoms were older (p < 0.001) and more often male (p = 0.046). A combination of chronic obstructive pulmonary disease (COPD) and high maximum chest computed tomography (CT) score was associated with disease progression. Maximum CT score (> 11) had the greatest predictive value for disease progression. The area under the receiver operating characteristic curve was 0.861 (95% confidence interval: 0.811-0.902).
Conclusions: Maximum CT score and COPD were associated with patient deterioration. Maximum CT score (> 11) was associated with severe illness.
Keywords: COPD; COVID-19; CT score; Chest CT; Multivariate regression; ROC.