tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Mar 10;22(1):240.
doi: 10.1186/s12879-022-07173-0.
Long-term immune responses in patients with confirmed novel coronavirus disease-2019: a 9-month prospective cohort study in Shanghai, China
Xiaohuan Gong[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Peng Cui[SUP] #[/SUP][SUP] 2 [/SUP], Huanyu Wu[SUP] #[/SUP][SUP] 4 [/SUP], Hao Pan[SUP] #[/SUP][SUP] 2 [/SUP], Zheng Teng[SUP] #[/SUP][SUP] 5 [/SUP], Fang Yuan[SUP] 5 [/SUP], Shenghua Mao[SUP] 2 [/SUP], Dechuan Kong[SUP] 2 [/SUP], Ruobing Han[SUP] 2 [/SUP], Xue Zhao[SUP] 5 [/SUP], Yaxu Zheng[SUP] 2 [/SUP], Wenjia Xiao[SUP] 2 [/SUP], Yiyi Zhu[SUP] 2 [/SUP], Qiwen Fang[SUP] 2 [/SUP], Sheng Lin[SUP] 2 [/SUP], Bihong Jin[SUP] 2 [/SUP], Ruilin Chu[SUP] 2 [/SUP], Chenyan Jiang[SUP] 2 [/SUP], Xiao Yu[SUP] 2 [/SUP], Qi Qiu[SUP] 2 [/SUP], Yihan Lu[SUP] 1 3 [/SUP], Weibing Wang[SUP] #[/SUP][SUP] 6 7 [/SUP], Chen Fu[SUP] #[/SUP][SUP] 8 [/SUP], Xiaodong Sun[SUP] #[/SUP][SUP] 9 [/SUP]
Affiliations
Abstract
Background: The duration of antibodies against SARS-CoV-2 in Covid-19 patients remains uncertain. Longitudinal serological studies are needed to prevent disease and transmission of the virus.
Methods: In 2020, 414 blood samples were tested, obtained from 157 confirmed Covid-19 patients, in a prospective cohort study in Shanghai.
Results: The seropositive rate of IgM peaked at 40.5% (17/42) within 1 month after illness onset and then declined. The seropositive rate of IgG was 90.6% (58/64) after 2 months, remained above 85% from 2 to 9 months and was 90.9% (40/44) after 9 months. Generalized estimating equations models suggested that IgM (P < 0.001) but not IgG significantly decreased over time. Age ≥ 40 years (adjusted odds ratio [aOR] 4.531; 95% confidence interval [CI] 1.879-10.932), and cigarette smoking (aOR 0.344; 95% CI 0.124-0.951) were associated with IgG, and age ≥ 40 years (aOR 2.820; 95% CI 1.579-5.036) was associated with IgM. After seroconversion, over 90% and 75.1% of subjects were estimated to remain IgG-positive 220 and 254 days, respectively. Of 1420 self-reported symptoms questionnaires, only 5% reported symptoms 9 months after onset.
Conclusions: In patients with a history of natural infection, anti-SARS-CoV-2 IgG is long-lived, being present for at least 9 months after illness onset. The long duration of natural immunity can mitigate and eliminate Covid-19 and the ongoing pandemic.
Keywords: Antibodies; Cohort study; Covid-19; Immunity; SARS-CoV-2.
. 2022 Mar 10;22(1):240.
doi: 10.1186/s12879-022-07173-0.
Long-term immune responses in patients with confirmed novel coronavirus disease-2019: a 9-month prospective cohort study in Shanghai, China
Xiaohuan Gong[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Peng Cui[SUP] #[/SUP][SUP] 2 [/SUP], Huanyu Wu[SUP] #[/SUP][SUP] 4 [/SUP], Hao Pan[SUP] #[/SUP][SUP] 2 [/SUP], Zheng Teng[SUP] #[/SUP][SUP] 5 [/SUP], Fang Yuan[SUP] 5 [/SUP], Shenghua Mao[SUP] 2 [/SUP], Dechuan Kong[SUP] 2 [/SUP], Ruobing Han[SUP] 2 [/SUP], Xue Zhao[SUP] 5 [/SUP], Yaxu Zheng[SUP] 2 [/SUP], Wenjia Xiao[SUP] 2 [/SUP], Yiyi Zhu[SUP] 2 [/SUP], Qiwen Fang[SUP] 2 [/SUP], Sheng Lin[SUP] 2 [/SUP], Bihong Jin[SUP] 2 [/SUP], Ruilin Chu[SUP] 2 [/SUP], Chenyan Jiang[SUP] 2 [/SUP], Xiao Yu[SUP] 2 [/SUP], Qi Qiu[SUP] 2 [/SUP], Yihan Lu[SUP] 1 3 [/SUP], Weibing Wang[SUP] #[/SUP][SUP] 6 7 [/SUP], Chen Fu[SUP] #[/SUP][SUP] 8 [/SUP], Xiaodong Sun[SUP] #[/SUP][SUP] 9 [/SUP]
Affiliations
- PMID: 35272627
- PMCID: PMC8907900
- DOI: 10.1186/s12879-022-07173-0
Abstract
Background: The duration of antibodies against SARS-CoV-2 in Covid-19 patients remains uncertain. Longitudinal serological studies are needed to prevent disease and transmission of the virus.
Methods: In 2020, 414 blood samples were tested, obtained from 157 confirmed Covid-19 patients, in a prospective cohort study in Shanghai.
Results: The seropositive rate of IgM peaked at 40.5% (17/42) within 1 month after illness onset and then declined. The seropositive rate of IgG was 90.6% (58/64) after 2 months, remained above 85% from 2 to 9 months and was 90.9% (40/44) after 9 months. Generalized estimating equations models suggested that IgM (P < 0.001) but not IgG significantly decreased over time. Age ≥ 40 years (adjusted odds ratio [aOR] 4.531; 95% confidence interval [CI] 1.879-10.932), and cigarette smoking (aOR 0.344; 95% CI 0.124-0.951) were associated with IgG, and age ≥ 40 years (aOR 2.820; 95% CI 1.579-5.036) was associated with IgM. After seroconversion, over 90% and 75.1% of subjects were estimated to remain IgG-positive 220 and 254 days, respectively. Of 1420 self-reported symptoms questionnaires, only 5% reported symptoms 9 months after onset.
Conclusions: In patients with a history of natural infection, anti-SARS-CoV-2 IgG is long-lived, being present for at least 9 months after illness onset. The long duration of natural immunity can mitigate and eliminate Covid-19 and the ongoing pandemic.
Keywords: Antibodies; Cohort study; Covid-19; Immunity; SARS-CoV-2.