tetano
Editor, Senior Moderator
BMC Infect Dis
. 2024 Jul 27;24(1):742.
doi: 10.1186/s12879-024-09646-w. Long-term effects of COVID-19 on endothelial function, arterial stiffness, and blood pressure in college students: a pre-post-controlled study
Jianwei Peng[SUP] #[/SUP][SUP] 1 [/SUP], Wenhuang Guo[SUP] #[/SUP][SUP] 1 [/SUP], Peilun Li[SUP] #[/SUP][SUP] 1 [/SUP], Lu Leng[SUP] 2 [/SUP], Dongdong Gao[SUP] 1 [/SUP], Zhendong Yu[SUP] 1 [/SUP], Jinglin Huang[SUP] 1 [/SUP], Jinghui Guo[SUP] 3 [/SUP], Shen Wang[SUP] 4 [/SUP], Min Hu[SUP] 5 [/SUP], Junhao Huang[SUP] 6 7 [/SUP]
Affiliations
Background: The COVID-19 has been shown to have negative effects on the cardiovascular system, but it is unclear how long these effects last in college students. This study aimed to assess the long-term impact of COVID-19 on arterial stiffness, endothelial function, and blood pressure in college students.
Methods: We enrolled 37 college students who had been infected with COVID-19 for more than 2 months. Brachial artery flow-mediated dilation (FMD) was used to assess endothelial function, while arterial stiffness was evaluated using the ABI Systems 100, including variables such as ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), carotid-femoral pulse wave velocity (cfPWV), heart rate (HR), and blood pressure (BP).
Results: Our results showed that FMD was significantly impaired after COVID-19 infection (p < 0.001), while cfPWV and systolic blood pressure (SBP) were significantly increased (p < 0.05). Simple linear regression models revealed a significant negative correlation between post-COVID-19 measurement time and baPWV change (p < 0.01), indicating an improvement in arterial stiffness over time. However, there was a significant positive correlation between post-COVID-19 measurement time and diastolic blood pressure (DBP) change (p < 0.05), suggesting an increase in BP over time. There were no significant differences in ABI and HR between pre- and post-COVID-19 measurements, and no significant correlations were observed with other variables (p > 0.05).
Conclusion: Our study demonstrated that COVID-19 has long-term detrimental effects on vascular function in college students. However, arterial stiffness tends to improve over time, while BP may exhibit the opposite trend.
Keywords: Blood pressure; Endothelial function; Post-acute COVID-19 syndrome; Vascular stiffness.
. 2024 Jul 27;24(1):742.
doi: 10.1186/s12879-024-09646-w. Long-term effects of COVID-19 on endothelial function, arterial stiffness, and blood pressure in college students: a pre-post-controlled study
Jianwei Peng[SUP] #[/SUP][SUP] 1 [/SUP], Wenhuang Guo[SUP] #[/SUP][SUP] 1 [/SUP], Peilun Li[SUP] #[/SUP][SUP] 1 [/SUP], Lu Leng[SUP] 2 [/SUP], Dongdong Gao[SUP] 1 [/SUP], Zhendong Yu[SUP] 1 [/SUP], Jinglin Huang[SUP] 1 [/SUP], Jinghui Guo[SUP] 3 [/SUP], Shen Wang[SUP] 4 [/SUP], Min Hu[SUP] 5 [/SUP], Junhao Huang[SUP] 6 7 [/SUP]
Affiliations
- PMID: 39068389
- PMCID: PMC11282677
- DOI: 10.1186/s12879-024-09646-w
Background: The COVID-19 has been shown to have negative effects on the cardiovascular system, but it is unclear how long these effects last in college students. This study aimed to assess the long-term impact of COVID-19 on arterial stiffness, endothelial function, and blood pressure in college students.
Methods: We enrolled 37 college students who had been infected with COVID-19 for more than 2 months. Brachial artery flow-mediated dilation (FMD) was used to assess endothelial function, while arterial stiffness was evaluated using the ABI Systems 100, including variables such as ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), carotid-femoral pulse wave velocity (cfPWV), heart rate (HR), and blood pressure (BP).
Results: Our results showed that FMD was significantly impaired after COVID-19 infection (p < 0.001), while cfPWV and systolic blood pressure (SBP) were significantly increased (p < 0.05). Simple linear regression models revealed a significant negative correlation between post-COVID-19 measurement time and baPWV change (p < 0.01), indicating an improvement in arterial stiffness over time. However, there was a significant positive correlation between post-COVID-19 measurement time and diastolic blood pressure (DBP) change (p < 0.05), suggesting an increase in BP over time. There were no significant differences in ABI and HR between pre- and post-COVID-19 measurements, and no significant correlations were observed with other variables (p > 0.05).
Conclusion: Our study demonstrated that COVID-19 has long-term detrimental effects on vascular function in college students. However, arterial stiffness tends to improve over time, while BP may exhibit the opposite trend.
Keywords: Blood pressure; Endothelial function; Post-acute COVID-19 syndrome; Vascular stiffness.