tetano
Editor, Senior Moderator
BMC Infect Dis
. 2021 Nov 24;21(1):1183.
doi: 10.1186/s12879-021-06881-3.
Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
Jia Li[SUP] #[/SUP][SUP] 1 [/SUP], Yali Zheng[SUP] #[/SUP][SUP] 1 [/SUP], Lili Zhao[SUP] 1 [/SUP], Zhihong Yue[SUP] 2 [/SUP], Feng Pan[SUP] 3 [/SUP], Yuehong Chen[SUP] 4 [/SUP], Bing Yu[SUP] 1 [/SUP], Yanwen Chen[SUP] 1 [/SUP], Guangyu Zhao[SUP] 4 [/SUP], Yusen Zhou[SUP] #[/SUP][SUP] 4 [/SUP], Zhancheng Gao[SUP] 5 [/SUP]
Affiliations
Abstract
Background: We investigate the long-term effects of SARS-CoV on patients' lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003-2004.
Methods: We enrolled 58 healthcare workers from Peking University People's Hospital who were infected with SARS-CoV in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera.
Results: After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL (CO), RV, and FEF[SUB]25-75[/SUB], respectively. 17 (30.4%) subjects had an mMRC score ≥ 2. Fourteen (25.5%) cases had residual CT abnormalities. T regulatory cells were a bit higher in the SARS survivors. IgG antibodies against SARS S-RBD protein and N protein were detected in 11 (18.97%) and 12 (20.69%) subjects, respectively. Subgroup analysis revealed that small airway dysfunction and CT abnormalities were more common in the severe group than in the non-severe group (57.1% vs 22.6%, 54.5% vs 6.1%, respectively, p < 0.05).
Conclusions: SARS-CoV could cause permanent damage to the lung, which requires early pulmonary rehabilitation. The long-lived immune memory response against coronavirus requires further studies to assess the potential benefit. Trial registration ClinicalTrials.gov, NCT03443102. Registered prospectively on 25 January 2018.
Keywords: HRCT; Pulmonary function test; Regulatory T cell; SARS-CoV specific IgG antibody; Severe acute respiratory syndrome (SARS).
. 2021 Nov 24;21(1):1183.
doi: 10.1186/s12879-021-06881-3.
Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years
Jia Li[SUP] #[/SUP][SUP] 1 [/SUP], Yali Zheng[SUP] #[/SUP][SUP] 1 [/SUP], Lili Zhao[SUP] 1 [/SUP], Zhihong Yue[SUP] 2 [/SUP], Feng Pan[SUP] 3 [/SUP], Yuehong Chen[SUP] 4 [/SUP], Bing Yu[SUP] 1 [/SUP], Yanwen Chen[SUP] 1 [/SUP], Guangyu Zhao[SUP] 4 [/SUP], Yusen Zhou[SUP] #[/SUP][SUP] 4 [/SUP], Zhancheng Gao[SUP] 5 [/SUP]
Affiliations
- PMID: 34819019
- DOI: 10.1186/s12879-021-06881-3
Abstract
Background: We investigate the long-term effects of SARS-CoV on patients' lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003-2004.
Methods: We enrolled 58 healthcare workers from Peking University People's Hospital who were infected with SARS-CoV in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera.
Results: After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL (CO), RV, and FEF[SUB]25-75[/SUB], respectively. 17 (30.4%) subjects had an mMRC score ≥ 2. Fourteen (25.5%) cases had residual CT abnormalities. T regulatory cells were a bit higher in the SARS survivors. IgG antibodies against SARS S-RBD protein and N protein were detected in 11 (18.97%) and 12 (20.69%) subjects, respectively. Subgroup analysis revealed that small airway dysfunction and CT abnormalities were more common in the severe group than in the non-severe group (57.1% vs 22.6%, 54.5% vs 6.1%, respectively, p < 0.05).
Conclusions: SARS-CoV could cause permanent damage to the lung, which requires early pulmonary rehabilitation. The long-lived immune memory response against coronavirus requires further studies to assess the potential benefit. Trial registration ClinicalTrials.gov, NCT03443102. Registered prospectively on 25 January 2018.
Keywords: HRCT; Pulmonary function test; Regulatory T cell; SARS-CoV specific IgG antibody; Severe acute respiratory syndrome (SARS).