tetano
Editor, Senior Moderator
BMC Infect Dis
. 2024 Feb 9;24(1):179.
doi: 10.1186/s12879-024-09055-z. Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE)
Olena Tsurkalenko[SUP] #[/SUP][SUP] 1 [/SUP], Dmitry Bulaev[SUP] #[/SUP][SUP] 2 [/SUP], Marc Paul O'Sullivan[SUP] 2 [/SUP], Chantal Snoeck[SUP] 2 [/SUP], Soumyabrata Ghosh[SUP] 3 [/SUP], Alexey Kolodkin[SUP] 2 [/SUP], Basile Rommes[SUP] 3 [/SUP], Piotr Gawron[SUP] 3 [/SUP], Carlos Vega Moreno[SUP] 3 [/SUP], Clarissa P C Gomes[SUP] 3 [/SUP], Anne Kaysen[SUP] 3 [/SUP], Jochen Ohnmacht[SUP] 2 [/SUP], Valerie E Schröder[SUP] 3 4 [/SUP], Lukas Pavelka[SUP] 2 4 [/SUP], Guilherme Ramos Meyers[SUP] 2 3 [/SUP], Laure Pauly[SUP] 2 [/SUP], Claire Pauly[SUP] 2 4 [/SUP], Anne-Marie Hanff[SUP] 2 3 5 [/SUP], Max Meyrath[SUP] 2 [/SUP], Anja Leist[SUP] 3 [/SUP], Estelle Sandt[SUP] 2 [/SUP], Gloria A Aguayo[SUP] 2 [/SUP], Magali Perquin[SUP] 2 [/SUP], Manon Gantenbein[SUP] 2 [/SUP], Tamir Abdelrahman[SUP] 6 [/SUP], Jochen Klucken[SUP] 2 3 [/SUP], Venkata Satagopam[SUP] 3 [/SUP], Christiane Hilger[SUP] 2 [/SUP], Jonathan Turner[SUP] 2 [/SUP], Michel Vaillant[SUP] 2 [/SUP], Joëlle V Fritz[SUP] 2 [/SUP], Markus Ollert[SUP] 2 [/SUP], Rejko Krüger[SUP] 2 3 4 [/SUP]; CON-VINCE consortium and the ORCHESTRA working group
Collaborators, Affiliations
Background: During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.
Methods: A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.
Results: One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.
Conclusion: The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research.
Trial registration: Trial registration number: NCT04379297, 10 April 2020.
Keywords: Coronavirus (COVID-19); Prevalence; Prospective cohort study; SARS-CoV-2.
. 2024 Feb 9;24(1):179.
doi: 10.1186/s12879-024-09055-z. Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE)
Olena Tsurkalenko[SUP] #[/SUP][SUP] 1 [/SUP], Dmitry Bulaev[SUP] #[/SUP][SUP] 2 [/SUP], Marc Paul O'Sullivan[SUP] 2 [/SUP], Chantal Snoeck[SUP] 2 [/SUP], Soumyabrata Ghosh[SUP] 3 [/SUP], Alexey Kolodkin[SUP] 2 [/SUP], Basile Rommes[SUP] 3 [/SUP], Piotr Gawron[SUP] 3 [/SUP], Carlos Vega Moreno[SUP] 3 [/SUP], Clarissa P C Gomes[SUP] 3 [/SUP], Anne Kaysen[SUP] 3 [/SUP], Jochen Ohnmacht[SUP] 2 [/SUP], Valerie E Schröder[SUP] 3 4 [/SUP], Lukas Pavelka[SUP] 2 4 [/SUP], Guilherme Ramos Meyers[SUP] 2 3 [/SUP], Laure Pauly[SUP] 2 [/SUP], Claire Pauly[SUP] 2 4 [/SUP], Anne-Marie Hanff[SUP] 2 3 5 [/SUP], Max Meyrath[SUP] 2 [/SUP], Anja Leist[SUP] 3 [/SUP], Estelle Sandt[SUP] 2 [/SUP], Gloria A Aguayo[SUP] 2 [/SUP], Magali Perquin[SUP] 2 [/SUP], Manon Gantenbein[SUP] 2 [/SUP], Tamir Abdelrahman[SUP] 6 [/SUP], Jochen Klucken[SUP] 2 3 [/SUP], Venkata Satagopam[SUP] 3 [/SUP], Christiane Hilger[SUP] 2 [/SUP], Jonathan Turner[SUP] 2 [/SUP], Michel Vaillant[SUP] 2 [/SUP], Joëlle V Fritz[SUP] 2 [/SUP], Markus Ollert[SUP] 2 [/SUP], Rejko Krüger[SUP] 2 3 4 [/SUP]; CON-VINCE consortium and the ORCHESTRA working group
Collaborators, Affiliations
- PMID: 38336649
- PMCID: PMC10858600
- DOI: 10.1186/s12879-024-09055-z
Background: During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.
Methods: A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.
Results: One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020-June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.
Conclusion: The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research.
Trial registration: Trial registration number: NCT04379297, 10 April 2020.
Keywords: Coronavirus (COVID-19); Prevalence; Prospective cohort study; SARS-CoV-2.