tetano
Editor, Senior Moderator
BMC Infect Dis
. 2022 Apr 15;22(1):382.
doi: 10.1186/s12879-022-07200-0.
Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease
Setareh Mamishi[SUP] 1 2 [/SUP], Babak Pourakbari[SUP] 3 4 [/SUP], Mehrzad Mehdizadeh[SUP] 5 6 [/SUP], Amene Navaeian[SUP] 2 [/SUP], Hamid Eshaghi[SUP] 2 [/SUP], Bahareh Yaghmaei[SUP] 7 [/SUP], Reihaneh Hosseinpour Sadeghi[SUP] 1 [/SUP], Shiva Poormohammadi[SUP] 1 [/SUP], Yasmine Mahmoudieh[SUP] 8 [/SUP], Shima Mahmoudi[SUP] 9 10 11 [/SUP]
Affiliations
Abstract
Background: The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological, clinical, laboratory, and imaging features of hospitalized patients with COVID-19 at an Iranian referral pediatrics hospital and to compare these parameters between hospitalized patients with and without severe disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well as deceased and discharged cases.
Methods: This study included hospitalized children and adolescents (≤ 18 years) with suspected COVID-19 who had positive results for SARS-CoV-2.
Results: Among the 262 patients with suspected COVID-19, 142 confirmed COVID-19 cases were included in the study. A total of 11 children were diagnosed as MIS-C. The majority of the cases with MIS-C were male, (n = 9, 82%) which is significantly higher than children (n = 61, 47%) with acute COVID-19 (P = 0.03). Fifty patients (35%) were shown to have a more severe form of COVID-19. Ninety percent of the cases (n = 45) with severe COVID-19 had comorbidities that was significantly higher than cases with non-severe or mild disease (n = 41, 45%; P < 0.0001). A mortality rate of 10% was reported (n = 14). Ninety-three percent of the deceased cases (n = 13) had comorbidities that were significantly higher than discharged patients (n = 73, 57%; P = 0.009).
Conclusion: The increasing number of children with severe COVID-19 is cause for great concern. Underlying diseases, mainly cardiovascular diseases, cancer, and malignancies, are associated with greater risk of development of severe COVID-19 and even death in children. On the other hand, pediatric patients with MIS-C usually develop a milder form of the disease. However, evaluation specific immunological responses in children to explore the delayed inflammatory syndrome are highly recommended.
Keywords: COVID-19; MIS-C; Mortality; SARS-CoV-2; Severity.
. 2022 Apr 15;22(1):382.
doi: 10.1186/s12879-022-07200-0.
Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease
Setareh Mamishi[SUP] 1 2 [/SUP], Babak Pourakbari[SUP] 3 4 [/SUP], Mehrzad Mehdizadeh[SUP] 5 6 [/SUP], Amene Navaeian[SUP] 2 [/SUP], Hamid Eshaghi[SUP] 2 [/SUP], Bahareh Yaghmaei[SUP] 7 [/SUP], Reihaneh Hosseinpour Sadeghi[SUP] 1 [/SUP], Shiva Poormohammadi[SUP] 1 [/SUP], Yasmine Mahmoudieh[SUP] 8 [/SUP], Shima Mahmoudi[SUP] 9 10 11 [/SUP]
Affiliations
- PMID: 35428202
- DOI: 10.1186/s12879-022-07200-0
Abstract
Background: The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (COVID-19) is still rising. The aim of this study was to describe the epidemiological, clinical, laboratory, and imaging features of hospitalized patients with COVID-19 at an Iranian referral pediatrics hospital and to compare these parameters between hospitalized patients with and without severe disease, multisystem inflammatory syndrome in children (MIS-C) and children with acute COVID-19, as well as deceased and discharged cases.
Methods: This study included hospitalized children and adolescents (≤ 18 years) with suspected COVID-19 who had positive results for SARS-CoV-2.
Results: Among the 262 patients with suspected COVID-19, 142 confirmed COVID-19 cases were included in the study. A total of 11 children were diagnosed as MIS-C. The majority of the cases with MIS-C were male, (n = 9, 82%) which is significantly higher than children (n = 61, 47%) with acute COVID-19 (P = 0.03). Fifty patients (35%) were shown to have a more severe form of COVID-19. Ninety percent of the cases (n = 45) with severe COVID-19 had comorbidities that was significantly higher than cases with non-severe or mild disease (n = 41, 45%; P < 0.0001). A mortality rate of 10% was reported (n = 14). Ninety-three percent of the deceased cases (n = 13) had comorbidities that were significantly higher than discharged patients (n = 73, 57%; P = 0.009).
Conclusion: The increasing number of children with severe COVID-19 is cause for great concern. Underlying diseases, mainly cardiovascular diseases, cancer, and malignancies, are associated with greater risk of development of severe COVID-19 and even death in children. On the other hand, pediatric patients with MIS-C usually develop a milder form of the disease. However, evaluation specific immunological responses in children to explore the delayed inflammatory syndrome are highly recommended.
Keywords: COVID-19; MIS-C; Mortality; SARS-CoV-2; Severity.