tetano
Editor, Senior Moderator
Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China
Hua Ding, Li Xie, Zhou Sun, Qing-Jun Kao, Ren-Jie Huang, Xu-Hui Yang, Chun-ping Huang, Yuan-Yuan Wen, Jing-Cao Pan, Xiao-Ying Pu, Tao Jin, Xiao-Hong Zhou, Lin Zheng, Jian Li and Feng-Juan Wang
Author Affiliations
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BMC Infectious Diseases 2014, 14:175 doi:10.1186/1471-2334-14-175
Published: 31 March 2014
Abstract (provisional)
Background
We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for contact tracing and disease prevention and control.
Methods
The cases confirmed from April 1 through May 1, 2013 were studied. Field epidemiologic surveys were conducted to collect the clinical and epidemiologic data. Case-related and environmental specimens were collected for etiologic detection.
Results
Thirty cases of human infection with avian influenza A(H7N9) virus were confirmed in Hangzhou from April 1 through May 1, 2013, including one pregnant woman and three deaths. The median age of the patients was 62 years (range: 38-86 years). Twenty-three of the patients were men (76.67%). The median duration between disease onset and occurrence of respiratory failure and confirmed diagnosis was 5 and 6 days, respectively. Maximum medical observation of 666 close contacts of the patients revealed no irregularity. Of 314 external environmental specimens, the overall positive detection rate of H7N9 nucleic acid was 28.98%. Eight districts of Hangzhou city had positive detections in the external environments, the highest rate being in Yuhang District (78.13%). Statistical analysis of the specimen collection locations indicates a significant difference between the case-linked locations and the non-case locations (chi2 = 16.563, p < 0.05) in terms of H7N9 viral nucleic acid detection rate. No epidemiologic link has been found among the 30 cases.
Conclusions
Most of the infected were retired individuals aged 60 years or older. Men made the majority. The cases are sporadic at present, with no evidence of human-to-human transmission. Exposures to poultry and live poultry markets may be important sources of infection.
full article
http://www.biomedcentral.com/content/pdf/1471-2334-14-175.pdf
Hua Ding, Li Xie, Zhou Sun, Qing-Jun Kao, Ren-Jie Huang, Xu-Hui Yang, Chun-ping Huang, Yuan-Yuan Wen, Jing-Cao Pan, Xiao-Ying Pu, Tao Jin, Xiao-Hong Zhou, Lin Zheng, Jian Li and Feng-Juan Wang
Author Affiliations
For all author emails, please log on.
BMC Infectious Diseases 2014, 14:175 doi:10.1186/1471-2334-14-175
Published: 31 March 2014
Abstract (provisional)
Background
We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for contact tracing and disease prevention and control.
Methods
The cases confirmed from April 1 through May 1, 2013 were studied. Field epidemiologic surveys were conducted to collect the clinical and epidemiologic data. Case-related and environmental specimens were collected for etiologic detection.
Results
Thirty cases of human infection with avian influenza A(H7N9) virus were confirmed in Hangzhou from April 1 through May 1, 2013, including one pregnant woman and three deaths. The median age of the patients was 62 years (range: 38-86 years). Twenty-three of the patients were men (76.67%). The median duration between disease onset and occurrence of respiratory failure and confirmed diagnosis was 5 and 6 days, respectively. Maximum medical observation of 666 close contacts of the patients revealed no irregularity. Of 314 external environmental specimens, the overall positive detection rate of H7N9 nucleic acid was 28.98%. Eight districts of Hangzhou city had positive detections in the external environments, the highest rate being in Yuhang District (78.13%). Statistical analysis of the specimen collection locations indicates a significant difference between the case-linked locations and the non-case locations (chi2 = 16.563, p < 0.05) in terms of H7N9 viral nucleic acid detection rate. No epidemiologic link has been found among the 30 cases.
Conclusions
Most of the infected were retired individuals aged 60 years or older. Men made the majority. The cases are sporadic at present, with no evidence of human-to-human transmission. Exposures to poultry and live poultry markets may be important sources of infection.
full article
http://www.biomedcentral.com/content/pdf/1471-2334-14-175.pdf