tetano
Editor, Senior Moderator
Blood
. 2022 Mar 3;blood.2021012249.
doi: 10.1182/blood.2021012249. Online ahead of print.
Cellular therapies for the treatment and prevention of SARS-CoV-2 infection
Susan Conway[SUP] 1 [/SUP], Michael D Keller[SUP] 1 [/SUP], Catherine M Bollard[SUP] 2 [/SUP]
Affiliations
Abstract
Patients with blood disorders who are immune suppressed are at increased risk for infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Sequelae of infection can include severe respiratory disease and/or prolonged duration of viral shedding. Cellular therapies may protect these vulnerable patients by providing anti-viral cellular immunity and/or immune modulation. In this recent Review of the field, phase I/II trials evaluating adoptive cellular therapies with virus-specific T cells or natural killer cells are described along with trials evaluating the safety, feasibility, and preliminary efficacy of immune modulating cellular therapies including regulatory T cells and mesenchymal stromal cells. In addition, the immunological basis for these therapies is discussed.
. 2022 Mar 3;blood.2021012249.
doi: 10.1182/blood.2021012249. Online ahead of print.
Cellular therapies for the treatment and prevention of SARS-CoV-2 infection
Susan Conway[SUP] 1 [/SUP], Michael D Keller[SUP] 1 [/SUP], Catherine M Bollard[SUP] 2 [/SUP]
Affiliations
- PMID: 35240679
- DOI: 10.1182/blood.2021012249
Abstract
Patients with blood disorders who are immune suppressed are at increased risk for infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Sequelae of infection can include severe respiratory disease and/or prolonged duration of viral shedding. Cellular therapies may protect these vulnerable patients by providing anti-viral cellular immunity and/or immune modulation. In this recent Review of the field, phase I/II trials evaluating adoptive cellular therapies with virus-specific T cells or natural killer cells are described along with trials evaluating the safety, feasibility, and preliminary efficacy of immune modulating cellular therapies including regulatory T cells and mesenchymal stromal cells. In addition, the immunological basis for these therapies is discussed.