tetano
Editor, Senior Moderator
Biosci Trends. 2020 Apr 5. doi: 10.5582/bst.2020.03058. [Epub ahead of print]
Macrolide treatment for COVID-19: Will this be the way forward?
Ohe M[SUP]1[/SUP], Shida H[SUP]1[/SUP], Jodo S[SUP]1[/SUP], Kusunoki Y[SUP]1[/SUP], Seki M[SUP]1[/SUP], Furuya K[SUP]1[/SUP], Goudarzi H[SUP]2[/SUP].
Author information
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Lately, the anti-viral effects of macrolides have attracted considerable attention. Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. We believe that treatments with macrolides alone or in combination with other drugs are promising and open the possibility of an international strategy to fight this emerging viral infection.
KEYWORDS:
COVID-19; SARS-CoV-2; macrolide
PMID:32249257DOI:10.5582/bst.2020.03058
Free full text
Macrolide treatment for COVID-19: Will this be the way forward?
Ohe M[SUP]1[/SUP], Shida H[SUP]1[/SUP], Jodo S[SUP]1[/SUP], Kusunoki Y[SUP]1[/SUP], Seki M[SUP]1[/SUP], Furuya K[SUP]1[/SUP], Goudarzi H[SUP]2[/SUP].
Author information
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Lately, the anti-viral effects of macrolides have attracted considerable attention. Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. We believe that treatments with macrolides alone or in combination with other drugs are promising and open the possibility of an international strategy to fight this emerging viral infection.
KEYWORDS:
COVID-19; SARS-CoV-2; macrolide
PMID:32249257DOI:10.5582/bst.2020.03058
Free full text