tetano
Editor, Senior Moderator
Biomed Pharmacother
. 2021 Jan;133:111064.
doi: 10.1016/j.biopha.2020.111064. Epub 2020 Nov 28.
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver
Han-Yu Lei[SUP] 1 [/SUP], Ying-He Ding[SUP] 1 [/SUP], Kai Nie[SUP] 1 [/SUP], Yin-Miao Dong[SUP] 1 [/SUP], Jia-Hao Xu[SUP] 1 [/SUP], Meng-Ling Yang[SUP] 1 [/SUP], Meng-Qi Liu[SUP] 1 [/SUP], Le Wei[SUP] 1 [/SUP], M I Nasser[SUP] 2 [/SUP], Lin-Yong Xu[SUP] 3 [/SUP], Ping Zhu[SUP] 4 [/SUP], Ming-Yi Zhao[SUP] 5 [/SUP]
Affiliations
Abstract
COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.
Keywords: COVID-19; Gastrointestinal tract; Gut-lung axis; Inflammatory cytokine storm; Liver injury; Liver transplant.
. 2021 Jan;133:111064.
doi: 10.1016/j.biopha.2020.111064. Epub 2020 Nov 28.
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver
Han-Yu Lei[SUP] 1 [/SUP], Ying-He Ding[SUP] 1 [/SUP], Kai Nie[SUP] 1 [/SUP], Yin-Miao Dong[SUP] 1 [/SUP], Jia-Hao Xu[SUP] 1 [/SUP], Meng-Ling Yang[SUP] 1 [/SUP], Meng-Qi Liu[SUP] 1 [/SUP], Le Wei[SUP] 1 [/SUP], M I Nasser[SUP] 2 [/SUP], Lin-Yong Xu[SUP] 3 [/SUP], Ping Zhu[SUP] 4 [/SUP], Ming-Yi Zhao[SUP] 5 [/SUP]
Affiliations
- PMID: 33378966
- PMCID: PMC7700011
- DOI: 10.1016/j.biopha.2020.111064
Abstract
COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early reported symptoms include fever, cough, and respiratory symptoms. There were few reports of digestive symptoms. However, with COVID-19 spreading worldwide, symptoms such as vomiting, diarrhoea, and abdominal pain have gained increasing attention. Research has found that angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 receptor, is strongly expressed in the gastrointestinal tract and liver. Whether theoretically or clinically, many studies have suggested a close connection between COVID-19 and the digestive system. In this review, we summarize the digestive symptoms reported in existing research, discuss the impact of SARS-CoV-2 on the gastrointestinal tract and liver, and determine the possible mechanisms and aetiology, such as cytokine storm. In-depth exploration of the relationship between COVID-19 and the digestive system is urgently needed.
Keywords: COVID-19; Gastrointestinal tract; Gut-lung axis; Inflammatory cytokine storm; Liver injury; Liver transplant.