Giuseppe
Emeritus
Biochem Biophys Res Commun. 2009 Aug 27. [Epub ahead of print]
Functional association between influenza A (H1N1) virus and human.
Huang T, Cui W, He ZS, Hu L, Liu F, Wen T, Li Y, Cai Y. - Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China; Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China.
Influenza A (H1N1) virus is a severe threat worldwide. It is important to gain a better understanding of the mechanism of the infection. In the paper, we established a computational framework to investigate the crosstalk between the virus and the host, by finding out the proteins that the virus is attacking. The targeted proteins were predicted by taking human proteins laid on the same GO functions or processes as the virus proteins. 101 core proteins were identified. The results provide some knowledge of the possible biological processes and molecular interactions caused by the viral infection, including the host responses.
PMID: 19716802 [PubMed - as supplied by publisher]
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Functional association between influenza A (H1N1) virus and human.
Huang T, Cui W, He ZS, Hu L, Liu F, Wen T, Li Y, Cai Y. - Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China; Shanghai Center for Bioinformation Technology, Shanghai 200235, P. R. China.
Influenza A (H1N1) virus is a severe threat worldwide. It is important to gain a better understanding of the mechanism of the infection. In the paper, we established a computational framework to investigate the crosstalk between the virus and the host, by finding out the proteins that the virus is attacking. The targeted proteins were predicted by taking human proteins laid on the same GO functions or processes as the virus proteins. 101 core proteins were identified. The results provide some knowledge of the possible biological processes and molecular interactions caused by the viral infection, including the host responses.
PMID: 19716802 [PubMed - as supplied by publisher]
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