tetano
Editor, Senior Moderator
Microb Pathog. 2017 Aug 18. pii: S0882-4010(17)30342-X. doi: 10.1016/j.micpath.2017.08.022. [Epub ahead of print]
[h=1]Avian Influenza A (H7N9) viruses isolated from patients with mild and fatal infection differ in pathogenicity and induction of cytokines.[/h] Zhou J[SUP]1[/SUP], Guo X[SUP]2[/SUP], Fang D[SUP]3[/SUP], Yu Y[SUP]3[/SUP], Si L[SUP]3[/SUP], Wang Y[SUP]3[/SUP], Zeng G[SUP]3[/SUP], Yan H[SUP]3[/SUP], Wu J[SUP]4[/SUP], Ke C[SUP]4[/SUP], Jiang L[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Since 2013, a novel Influenza A (H7N9) virus strain has continued to circulate within poultry and causing human disease. Influenza A (H7N9) virus results in two types of infection: mild and severe. The different results of clinical findings may be related with host susceptibility and characteristics of the virus itself. In order to investigate potential pathogenesis of Influenza A (H7N9) virus, we performed pathogenecity and cytokines analysis of two isolates, A/Guangdong/6/2013 H7N9 virus (GD-6) from a patient with a mild infection, and A/Guangdong/7/2013 H7N9 virus (GD-7) from a patient with a fatal infection. We found that GD-7 replicated to higher levels than GD-6 in human peripheral blood mononuclear cells (PBMCs), lung tissues, and mice. Furthermore, GD-7 infection resulted in more severe lung damage in mice lung tissues than GD-6 infection. GD-7 elicited higher levels of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) than GD-6 did. In conclusion, GD-7 was more pathogenic and induced higher levels of proinflammatory cytokines than GD-6 did.
Copyright ? 2017. Published by Elsevier Ltd.
PMID: 28826765 DOI: 10.1016/j.micpath.2017.08.022
[h=1]Avian Influenza A (H7N9) viruses isolated from patients with mild and fatal infection differ in pathogenicity and induction of cytokines.[/h] Zhou J[SUP]1[/SUP], Guo X[SUP]2[/SUP], Fang D[SUP]3[/SUP], Yu Y[SUP]3[/SUP], Si L[SUP]3[/SUP], Wang Y[SUP]3[/SUP], Zeng G[SUP]3[/SUP], Yan H[SUP]3[/SUP], Wu J[SUP]4[/SUP], Ke C[SUP]4[/SUP], Jiang L[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Since 2013, a novel Influenza A (H7N9) virus strain has continued to circulate within poultry and causing human disease. Influenza A (H7N9) virus results in two types of infection: mild and severe. The different results of clinical findings may be related with host susceptibility and characteristics of the virus itself. In order to investigate potential pathogenesis of Influenza A (H7N9) virus, we performed pathogenecity and cytokines analysis of two isolates, A/Guangdong/6/2013 H7N9 virus (GD-6) from a patient with a mild infection, and A/Guangdong/7/2013 H7N9 virus (GD-7) from a patient with a fatal infection. We found that GD-7 replicated to higher levels than GD-6 in human peripheral blood mononuclear cells (PBMCs), lung tissues, and mice. Furthermore, GD-7 infection resulted in more severe lung damage in mice lung tissues than GD-6 infection. GD-7 elicited higher levels of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) than GD-6 did. In conclusion, GD-7 was more pathogenic and induced higher levels of proinflammatory cytokines than GD-6 did.
Copyright ? 2017. Published by Elsevier Ltd.
PMID: 28826765 DOI: 10.1016/j.micpath.2017.08.022