Avian, human flu coinfection reported in Indonesian teen

[gsgs]

Re: Avian, human flu coinfection reported in Indonesian teen

vaccination and natural infection are still often different.
We have cell-mediated and humoral immunity, the interactions
are unclear.
It could also be that a life,attenuated vaccine like flumist will work
much better for H5.

Fascinating how new flu-viruses could wipe out pre-existing
strains in 1918,1957(almost),1968,
that ability could maybe be used as ultima ratio in a severe pandemic.

The military may have created already a low-path highly
infective flu...

 

[Giuseppe]

Re: Avian, human flu coinfection reported in Indonesian teen

A Commentary by Promed Moderator:

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[The reassuring outcome of these observations is that co-infection of
a human patient by seasonal and avian strains of influenza A virus is
not sufficient to yield recombinants or genome reassortants that
might evolve into a pandemic strain of influenza A virus. However the
relevance of these data is doubtful.

The RT-PCR assays indicated that the patient was co-infected by an H3N2 human influenza virus and H5N1avian influenza virus.

However, the patient displayed only mild signs and symptoms of infection, which together with the negative H5N1 convalescent serum titre suggest that the avian virus did not multiply extensively (or at all) in the human host.

Few people have developed severe H5N1 virus infections despite the very large number of people exposed to infection, suggesting a significant genetic
component in susceptibility.

Until co-infection occurs in such a genetically susceptible individual, the level of risk associated with co-infection will remain undefined. - Mod.CP]

[The risk of unintentional cross-contamination in RT-PCR tests is high. It would be desirable to have confirmation of these results from an international reference lab. - Mod.JW]
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http://apex.oracle.com/pls/otn/f?p=..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,71875
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[Farmer]

Re: Avian, human flu coinfection reported in Indonesian teen

I just returned from ICEID.

During the presentation of the paper, the girl was described as having mild symptoms, no pneumonia. she apparently survived infection.

Her mother was diagnosed with H3N2 influenza soon after the girl, but was repeatedly negative for H5 by PCR. The mother became very ill and was hospitalized with pneumonia. I hope that this case report is published.

I will try to post more about the meeting later tonight.