Gert van der Hoek
In Memoriam - Editor, Senior Moderator
Q fever seroprevalence in metropolitan samples is similar to rural/remote samples in Queensland, Australia.
Tozer SJ, Lambert SB, Sloots TP, Nissen MD.
Queensland Paediatric Infectious Diseases Laboratory, SASVRC, Queensland Children's Medical Research Institute, Queensland Children's Health Service and The University of Queensland, Queensland, Australia, s.tozer@uq.edu.au.
Abstract
Q fever is a vaccine preventable disease; however, despite this, high notification numbers are still recorded annually in Australia. We investigated the seroprevalence of Coxiella burnetii, the Q fever agent, in a Queensland sample population.
Notification data (N = 6425) from 1984-2008 were collated, identifying high risk areas of Q fever exposure. Of these 177 were recorded in children.
Serum samples were collected from Queensland and screened using both an immunoflourescence assay at 1:10 dilution and a commercially available ELISA kit. Results were collated based on age, geographical location and sex.
From 1988 Queensland samples screened, 103 were identified as Q fever IgG-positive, giving a seroprevalence of 5.2% (95% CI 4.3-6.2%). Seroprevalence in the rural/remote population was 5.3% (95% CI 4.6-6.6%), and the metropolitan Brisbane population, which is considered not at risk, was 5.0% (95% CI 3.7-6.7%). Sixty-three seropositive males and 40 females were identified, along with an increase in seropositivity with increasing age. The seropositivity of children was 1.3% (95% CI 0.7-2.3%) from 844 samples.
We have shown that both metropolitan and paediatric populations which are considered low risk of Coxiella exposure have surprisingly high seropositivity.
These emerging groups require further investigation and consideration for the introduction of preventive measures.
Pubmed
Tozer SJ, Lambert SB, Sloots TP, Nissen MD.
Queensland Paediatric Infectious Diseases Laboratory, SASVRC, Queensland Children's Medical Research Institute, Queensland Children's Health Service and The University of Queensland, Queensland, Australia, s.tozer@uq.edu.au.
Abstract
Q fever is a vaccine preventable disease; however, despite this, high notification numbers are still recorded annually in Australia. We investigated the seroprevalence of Coxiella burnetii, the Q fever agent, in a Queensland sample population.
Notification data (N = 6425) from 1984-2008 were collated, identifying high risk areas of Q fever exposure. Of these 177 were recorded in children.
Serum samples were collected from Queensland and screened using both an immunoflourescence assay at 1:10 dilution and a commercially available ELISA kit. Results were collated based on age, geographical location and sex.
From 1988 Queensland samples screened, 103 were identified as Q fever IgG-positive, giving a seroprevalence of 5.2% (95% CI 4.3-6.2%). Seroprevalence in the rural/remote population was 5.3% (95% CI 4.6-6.6%), and the metropolitan Brisbane population, which is considered not at risk, was 5.0% (95% CI 3.7-6.7%). Sixty-three seropositive males and 40 females were identified, along with an increase in seropositivity with increasing age. The seropositivity of children was 1.3% (95% CI 0.7-2.3%) from 844 samples.
We have shown that both metropolitan and paediatric populations which are considered low risk of Coxiella exposure have surprisingly high seropositivity.
These emerging groups require further investigation and consideration for the introduction of preventive measures.
Pubmed