Mary Wilson
Well-known member
Published online June 11, 2021. doi:10.1001/jamaneurol.2021.2004
Tom Aschman, MD[SUP]1[/SUP]; Julia Schneider, MSc[SUP]2[/SUP]; Selina Greuel, MD[SUP]3[/SUP]; et al
Key Points
Question Is there a COVID-19–associated myopathy, and is it a viral or postviral phenomenon?
Findings In this case-control autopsy study, 26 of 43 individuals (60%) who had died with a diagnosis of COVID-19 showed signs of muscle inflammation, ranging from mild to severe inflammatory myopathy. Inflammation was more pronounced in patients who were chronically ill and those who had seroconverted to SARS-CoV-2 than those who died after acute or subacute courses of COVID-19 and those who died of other illnesses, and no evidence was found for a direct infection of muscle tissue.
Meaning In this study, SARS-CoV-2 was associated with an immune-mediated myopathy.
Abstract
Importance Myalgia, increased levels of creatine kinase, and persistent muscle weakness have been reported in patients with COVID-19.
Objective To study skeletal muscle and myocardial inflammation in patients with COVID-19 who had died.
Design, Setting, and Participants This case-control autopsy series was conducted in a university hospital as a multidisciplinary postmortem investigation. Patients with COVID-19 or other critical illnesses who had died between March 2020 and February 2021 and on whom an autopsy was performed were included. Individuals for whom informed consent to autopsy was available and the postmortem interval was less than 6 days were randomly selected. Individuals who were infected with SARS-CoV-2 per polymerase chain reaction test results and had clinical features suggestive of COVID-19 were compared with individuals with negative SARS-CoV-2 polymerase chain reaction test results and an absence of clinical features suggestive of COVID-19.
...
https://jamanetwork.com/journals/ja...ign=ftm_links&utm_content=tfl&utm_term=061121
Tom Aschman, MD[SUP]1[/SUP]; Julia Schneider, MSc[SUP]2[/SUP]; Selina Greuel, MD[SUP]3[/SUP]; et al
Key Points
Question Is there a COVID-19–associated myopathy, and is it a viral or postviral phenomenon?
Findings In this case-control autopsy study, 26 of 43 individuals (60%) who had died with a diagnosis of COVID-19 showed signs of muscle inflammation, ranging from mild to severe inflammatory myopathy. Inflammation was more pronounced in patients who were chronically ill and those who had seroconverted to SARS-CoV-2 than those who died after acute or subacute courses of COVID-19 and those who died of other illnesses, and no evidence was found for a direct infection of muscle tissue.
Meaning In this study, SARS-CoV-2 was associated with an immune-mediated myopathy.
Abstract
Importance Myalgia, increased levels of creatine kinase, and persistent muscle weakness have been reported in patients with COVID-19.
Objective To study skeletal muscle and myocardial inflammation in patients with COVID-19 who had died.
Design, Setting, and Participants This case-control autopsy series was conducted in a university hospital as a multidisciplinary postmortem investigation. Patients with COVID-19 or other critical illnesses who had died between March 2020 and February 2021 and on whom an autopsy was performed were included. Individuals for whom informed consent to autopsy was available and the postmortem interval was less than 6 days were randomly selected. Individuals who were infected with SARS-CoV-2 per polymerase chain reaction test results and had clinical features suggestive of COVID-19 were compared with individuals with negative SARS-CoV-2 polymerase chain reaction test results and an absence of clinical features suggestive of COVID-19.
...
https://jamanetwork.com/journals/ja...ign=ftm_links&utm_content=tfl&utm_term=061121