tetano
Editor, Senior Moderator
Arterioscler Thromb Vasc Biol
. 2020 Sep 22;ATVBAHA120314515.
doi: 10.1161/ATVBAHA.120.314515. Online ahead of print.
COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical, and Translational Research Questions
Shari B Brosnahan[SUP] 1 [/SUP], Annemijn H Jonkman[SUP] 2 3 [/SUP], Matthias C Kugler[SUP] 1 [/SUP], John S Munger[SUP] 1 [/SUP], David A Kaufman[SUP] 1 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.
Keywords: COVID-19; diaphragm; infection; respiratory system; thromboembolism.
. 2020 Sep 22;ATVBAHA120314515.
doi: 10.1161/ATVBAHA.120.314515. Online ahead of print.
COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical, and Translational Research Questions
Shari B Brosnahan[SUP] 1 [/SUP], Annemijn H Jonkman[SUP] 2 3 [/SUP], Matthias C Kugler[SUP] 1 [/SUP], John S Munger[SUP] 1 [/SUP], David A Kaufman[SUP] 1 [/SUP]
Affiliations
- PMID: 32960072
- DOI: 10.1161/ATVBAHA.120.314515
Abstract
The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.
Keywords: COVID-19; diaphragm; infection; respiratory system; thromboembolism.