tetano
Editor, Senior Moderator
Appl Microbiol Biotechnol
. 2020 Aug 11;1-9.
doi: 10.1007/s00253-020-10814-6. Online ahead of print.
The microbial coinfection in COVID-19
Xi Chen[SUP] 1 2 [/SUP], Binyou Liao[SUP] 1 [/SUP], Lei Cheng[SUP] 1 2 [/SUP], Xian Peng[SUP] 1 [/SUP], Xin Xu[SUP] 1 2 [/SUP], Yuqing Li[SUP] 1 [/SUP], Tao Hu[SUP] 1 2 [/SUP], Jiyao Li[SUP] 1 2 [/SUP], Xuedong Zhou[SUP] 3 4 [/SUP], Biao Ren[SUP] 5 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS: • Microbial coinfection is a nonnegligible factor in COVID-19. • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. • Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.
Keywords: COVID-19; Coinfection; Microorganism; SARS-CoV-2.
. 2020 Aug 11;1-9.
doi: 10.1007/s00253-020-10814-6. Online ahead of print.
The microbial coinfection in COVID-19
Xi Chen[SUP] 1 2 [/SUP], Binyou Liao[SUP] 1 [/SUP], Lei Cheng[SUP] 1 2 [/SUP], Xian Peng[SUP] 1 [/SUP], Xin Xu[SUP] 1 2 [/SUP], Yuqing Li[SUP] 1 [/SUP], Tao Hu[SUP] 1 2 [/SUP], Jiyao Li[SUP] 1 2 [/SUP], Xuedong Zhou[SUP] 3 4 [/SUP], Biao Ren[SUP] 5 [/SUP]
Affiliations
- PMID: 32780290
- PMCID: PMC7417782
- DOI: 10.1007/s00253-020-10814-6
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS: • Microbial coinfection is a nonnegligible factor in COVID-19. • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. • Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.
Keywords: COVID-19; Coinfection; Microorganism; SARS-CoV-2.