tetano
Editor, Senior Moderator
Antiviral Res
. 2022 Jun 20;105369.
doi: 10.1016/j.antiviral.2022.105369. Online ahead of print.
Influenza A virus polymerase acidic protein E23R substitution is a marker of reduced susceptibility to baloxavir
Jeremy C Jones[SUP] 1 [/SUP], Samuel W Rovito[SUP] 2 [/SUP], Melissa K Penaflor[SUP] 2 [/SUP], Richard J Webby[SUP] 2 [/SUP], Elena A Govorkova[SUP] 2 [/SUP]
Affiliations
Abstract
In our ongoing efforts to identify baloxavir resistance markers, we demonstrated that the influenza A polymerase acidic (PA) protein E23R substitution is genetically stable, increases baloxavir EC[SUB]50[/SUB] values (13- to 19-fold vs. wild-type), synergizes with PA I38T, and only modestly decreases viral fitness. E23R is, therefore, a potential threat to baloxavir treatment efficacy.
Keywords: Antiviral; Baloxavir; E23R; Endonuclease; Influenza; Polymerase acidic.
. 2022 Jun 20;105369.
doi: 10.1016/j.antiviral.2022.105369. Online ahead of print.
Influenza A virus polymerase acidic protein E23R substitution is a marker of reduced susceptibility to baloxavir
Jeremy C Jones[SUP] 1 [/SUP], Samuel W Rovito[SUP] 2 [/SUP], Melissa K Penaflor[SUP] 2 [/SUP], Richard J Webby[SUP] 2 [/SUP], Elena A Govorkova[SUP] 2 [/SUP]
Affiliations
- PMID: 35738347
- DOI: 10.1016/j.antiviral.2022.105369
Abstract
In our ongoing efforts to identify baloxavir resistance markers, we demonstrated that the influenza A polymerase acidic (PA) protein E23R substitution is genetically stable, increases baloxavir EC[SUB]50[/SUB] values (13- to 19-fold vs. wild-type), synergizes with PA I38T, and only modestly decreases viral fitness. E23R is, therefore, a potential threat to baloxavir treatment efficacy.
Keywords: Antiviral; Baloxavir; E23R; Endonuclease; Influenza; Polymerase acidic.