tetano
Editor, Senior Moderator
Antiviral Res
. 2023 Mar 3;105556.
doi: 10.1016/j.antiviral.2023.105556. Online ahead of print.
Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine
Changrui Lu[SUP] 1 [/SUP], Yuntao Zhang[SUP] 2 [/SUP], Xiaohu Liu[SUP] 3 [/SUP], Fujun Hou[SUP] 3 [/SUP], Rujie Cai[SUP] 1 [/SUP], Zhibin Yu[SUP] 3 [/SUP], Fei Liu[SUP] 1 [/SUP], Guohuan Yang[SUP] 1 [/SUP], Jun Ding[SUP] 3 [/SUP], Jiang Xu[SUP] 3 [/SUP], Xianwu Hua[SUP] 3 [/SUP], Xinhua Cheng[SUP] 1 [/SUP], Xinping Pan[SUP] 1 [/SUP], Lianxiao Liu[SUP] 1 [/SUP], Kang Lin[SUP] 1 [/SUP], Zejun Wang[SUP] 4 [/SUP], Xinguo Li[SUP] 4 [/SUP], Jia Lu[SUP] 4 [/SUP], Qiu Zhang[SUP] 4 [/SUP], Yuwei Li[SUP] 4 [/SUP], Chunxia Hu[SUP] 4 [/SUP], Huifen Fan[SUP] 4 [/SUP], Xiaoke Liu[SUP] 4 [/SUP], Hui Wang[SUP] 4 [/SUP], Rui Jia[SUP] 2 [/SUP], Fangjingwei Xu[SUP] 2 [/SUP], Xuewei Wang[SUP] 2 [/SUP], Hongwei Huang[SUP] 5 [/SUP], Ronghua Zhao[SUP] 5 [/SUP], Jing Li[SUP] 6 [/SUP], Hang Cheng[SUP] 6 [/SUP], William Jia[SUP] 7 [/SUP], Xiaoming Yang[SUP] 8 [/SUP]
Affiliations
Abstract
The coronavirus SARS-CoV-2 has mutated quickly and caused significant global damage. This study characterizes two mRNA vaccines ZSVG-02 (Delta) and ZSVG-02-O (Omicron BA.1), and associating heterologous prime-boost strategy following the prime of a most widely administrated inactivated whole-virus vaccine (BBIBP-CorV). The ZSVG-02-O induces neutralizing antibodies that effectively cross-react with Omicron subvariants. In naïve animals, ZSVG-02 or ZSVG-02-O induce humoral responses skewed to the vaccine's targeting strains, but cellular immune responses cross-react to all variants of concern (VOCs) tested. Following heterologous prime-boost regimes, animals present comparable neutralizing antibody levels and superior protection against Delta and Omicron BA.1variants. Single-boost only generated ancestral and omicron dual-responsive antibodies, probably by "recall" and "reshape" the prime immunity. New Omicron-specific antibody populations, however, appeared only following the second boost with ZSVG-02-O. Overall, our results support a heterologous boost with ZSVG-02-O, providing the best protection against current VOCs in inactivated virus vaccine-primed populations.
. 2023 Mar 3;105556.
doi: 10.1016/j.antiviral.2023.105556. Online ahead of print.
Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine
Changrui Lu[SUP] 1 [/SUP], Yuntao Zhang[SUP] 2 [/SUP], Xiaohu Liu[SUP] 3 [/SUP], Fujun Hou[SUP] 3 [/SUP], Rujie Cai[SUP] 1 [/SUP], Zhibin Yu[SUP] 3 [/SUP], Fei Liu[SUP] 1 [/SUP], Guohuan Yang[SUP] 1 [/SUP], Jun Ding[SUP] 3 [/SUP], Jiang Xu[SUP] 3 [/SUP], Xianwu Hua[SUP] 3 [/SUP], Xinhua Cheng[SUP] 1 [/SUP], Xinping Pan[SUP] 1 [/SUP], Lianxiao Liu[SUP] 1 [/SUP], Kang Lin[SUP] 1 [/SUP], Zejun Wang[SUP] 4 [/SUP], Xinguo Li[SUP] 4 [/SUP], Jia Lu[SUP] 4 [/SUP], Qiu Zhang[SUP] 4 [/SUP], Yuwei Li[SUP] 4 [/SUP], Chunxia Hu[SUP] 4 [/SUP], Huifen Fan[SUP] 4 [/SUP], Xiaoke Liu[SUP] 4 [/SUP], Hui Wang[SUP] 4 [/SUP], Rui Jia[SUP] 2 [/SUP], Fangjingwei Xu[SUP] 2 [/SUP], Xuewei Wang[SUP] 2 [/SUP], Hongwei Huang[SUP] 5 [/SUP], Ronghua Zhao[SUP] 5 [/SUP], Jing Li[SUP] 6 [/SUP], Hang Cheng[SUP] 6 [/SUP], William Jia[SUP] 7 [/SUP], Xiaoming Yang[SUP] 8 [/SUP]
Affiliations
- PMID: 36871919
- DOI: 10.1016/j.antiviral.2023.105556
Abstract
The coronavirus SARS-CoV-2 has mutated quickly and caused significant global damage. This study characterizes two mRNA vaccines ZSVG-02 (Delta) and ZSVG-02-O (Omicron BA.1), and associating heterologous prime-boost strategy following the prime of a most widely administrated inactivated whole-virus vaccine (BBIBP-CorV). The ZSVG-02-O induces neutralizing antibodies that effectively cross-react with Omicron subvariants. In naïve animals, ZSVG-02 or ZSVG-02-O induce humoral responses skewed to the vaccine's targeting strains, but cellular immune responses cross-react to all variants of concern (VOCs) tested. Following heterologous prime-boost regimes, animals present comparable neutralizing antibody levels and superior protection against Delta and Omicron BA.1variants. Single-boost only generated ancestral and omicron dual-responsive antibodies, probably by "recall" and "reshape" the prime immunity. New Omicron-specific antibody populations, however, appeared only following the second boost with ZSVG-02-O. Overall, our results support a heterologous boost with ZSVG-02-O, providing the best protection against current VOCs in inactivated virus vaccine-primed populations.