tetano
Editor, Senior Moderator
Antioxid Redox Signal
. 2020 Jun 11.
doi: 10.1089/ars.2020.8142. Online ahead of print.
IS ALBUMIN PREDICTOR OF MORTALITY IN COVID-19 ?
Francesco Violi[SUP] 1 [/SUP], Roberto Cangemi[SUP] 2 [/SUP], Giulio Francesco Romiti[SUP] 3 [/SUP], Giancarlo Ceccarelli[SUP] 4 [/SUP], Alessandra Oliva[SUP] 5 [/SUP], Francesco Alessandri[SUP] 6 [/SUP], Matteo Pirro[SUP] 7 [/SUP], Pasquale Pignatelli[SUP] 8 [/SUP], Miriam Lichtner[SUP] 9 [/SUP], Anna Carraro[SUP] 10 [/SUP], Francesco Cipollone[SUP] 11 [/SUP], Damiano d'ardes[SUP] 12 [/SUP], Francesco Pugliese[SUP] 13 [/SUP], Claudio Mastroianni[SUP] 14 [/SUP]
Affiliations
Abstract
Coronavirus 2019 (Covid-19) is a pandemic associated with a high risk of mortality. Human serum albumin (HSA) is an acute phase reactant with antioxidant property, however its behavior and impact on survival in Covid-19 patients has never been studied so far. Among 319 Covid-19 patients followed-up for a median of 19 days, 64 died. Compared to survivors, non-survivors had more prevalence of Intensive care unit (ICU) admission, chronic obstructive pulmonary disease (COPD), heart failure, elevated levels of D-dimer, hs-CRP and troponins and lower values of albumin. At the Cox regression analysis, albumin (HR: 0.38, 95% CI: 0.23-0.63, p<0.001) and age (HR: 1.03, 95% CI: 1.01-1.06, p=0.001) were independently associated with mortality, irrespective of adjustment for sex, ICU admission, heart failure, COPD and hs-CRP levels. Our observation leads to the hypothesis that HSA analysis may be used to identify patients at higher risk of death in Covid-19 patients.
. 2020 Jun 11.
doi: 10.1089/ars.2020.8142. Online ahead of print.
IS ALBUMIN PREDICTOR OF MORTALITY IN COVID-19 ?
Francesco Violi[SUP] 1 [/SUP], Roberto Cangemi[SUP] 2 [/SUP], Giulio Francesco Romiti[SUP] 3 [/SUP], Giancarlo Ceccarelli[SUP] 4 [/SUP], Alessandra Oliva[SUP] 5 [/SUP], Francesco Alessandri[SUP] 6 [/SUP], Matteo Pirro[SUP] 7 [/SUP], Pasquale Pignatelli[SUP] 8 [/SUP], Miriam Lichtner[SUP] 9 [/SUP], Anna Carraro[SUP] 10 [/SUP], Francesco Cipollone[SUP] 11 [/SUP], Damiano d'ardes[SUP] 12 [/SUP], Francesco Pugliese[SUP] 13 [/SUP], Claudio Mastroianni[SUP] 14 [/SUP]
Affiliations
- PMID: 32524832
- DOI: 10.1089/ars.2020.8142
Abstract
Coronavirus 2019 (Covid-19) is a pandemic associated with a high risk of mortality. Human serum albumin (HSA) is an acute phase reactant with antioxidant property, however its behavior and impact on survival in Covid-19 patients has never been studied so far. Among 319 Covid-19 patients followed-up for a median of 19 days, 64 died. Compared to survivors, non-survivors had more prevalence of Intensive care unit (ICU) admission, chronic obstructive pulmonary disease (COPD), heart failure, elevated levels of D-dimer, hs-CRP and troponins and lower values of albumin. At the Cox regression analysis, albumin (HR: 0.38, 95% CI: 0.23-0.63, p<0.001) and age (HR: 1.03, 95% CI: 1.01-1.06, p=0.001) were independently associated with mortality, irrespective of adjustment for sex, ICU admission, heart failure, COPD and hs-CRP levels. Our observation leads to the hypothesis that HSA analysis may be used to identify patients at higher risk of death in Covid-19 patients.