Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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The Target of Daptomycin is Absent from Escherichia coli and other Gram-Negative Pathogens
Christopher P. Randall, Katherine R. Mariner, Ian Chopra and Alex J. O'Neill*
Author Affiliations: Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
ABSTRACT
Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like Escherichia coli owing to the permeability barrier presented by the outer membrane and/or the action of efflux transporters. When these intrinsic resistance mechanisms are artificially compromised, such agents almost invariably demonstrate antibacterial activity against Gram-negatives. Here we show that this is not the case for the antibiotic daptomycin, whose target appears to be absent from E. coli and other Gram-negative pathogens.
FOOTNOTES
* Corresponding author. Mailing address: Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone +44 (0)113 343 5600, Fax +44 (0)113 343 5638, E-mail: a.j.oneill@leeds.ac.uk
Copyright ? 2012, American Society for Microbiology. All Rights Reserved.
-Author Affiliations: Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
ABSTRACT
Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like Escherichia coli owing to the permeability barrier presented by the outer membrane and/or the action of efflux transporters. When these intrinsic resistance mechanisms are artificially compromised, such agents almost invariably demonstrate antibacterial activity against Gram-negatives. Here we show that this is not the case for the antibiotic daptomycin, whose target appears to be absent from E. coli and other Gram-negative pathogens.
FOOTNOTES
* Corresponding author. Mailing address: Antimicrobial Research Centre and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone +44 (0)113 343 5600, Fax +44 (0)113 343 5638, E-mail: a.j.oneill@leeds.ac.uk
Copyright ? 2012, American Society for Microbiology. All Rights Reserved.
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