Giuseppe
Emeritus
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Potent in vitro antibacterial activity of DS-8587, a new generation of broad spectrum quinolone, against Acinetobacter baumannii
Saito Higuchi 1,2,*, Yoshikuni Onodera 1, Megumi Chiba 1, Kazuki Hoshino 1 and Naomasa Gotoh 2
Author Affiliations: <SUP>1</SUP>Biological Research Laboratories, Daiichi Sankyo, Co., Ltd., Tokyo, Japan <SUP>2</SUP>Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Kyoto, Japan
ABSTRACT
We investigated the in vitro activity of DS-8587, a new generation of fluoroquinolone, against Acinetobacter baumannii. The MICs against clinical isolates and inhibitory activity against target enzymes of DS-8587 was superior to ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps and frequency of single-step mutations with DS-8587 was lower as compared to those with ciprofloxacin. DS-8587 might be an effective agent against A. baumannii infection.
FOOTNOTES
* Corresponding author: Saito Higuchi, Biological Research Laboratories, Daiichi Sankyo Co., Ltd., 16-13, 1-Chome Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan, Tel: 81-3-5696-3915, Fax: 81-3-5696-4264, higuchi.saito.ir@daiichisankyo.co.jp
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
-Saito Higuchi 1,2,*, Yoshikuni Onodera 1, Megumi Chiba 1, Kazuki Hoshino 1 and Naomasa Gotoh 2
Author Affiliations: <SUP>1</SUP>Biological Research Laboratories, Daiichi Sankyo, Co., Ltd., Tokyo, Japan <SUP>2</SUP>Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Kyoto, Japan
ABSTRACT
We investigated the in vitro activity of DS-8587, a new generation of fluoroquinolone, against Acinetobacter baumannii. The MICs against clinical isolates and inhibitory activity against target enzymes of DS-8587 was superior to ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps and frequency of single-step mutations with DS-8587 was lower as compared to those with ciprofloxacin. DS-8587 might be an effective agent against A. baumannii infection.
FOOTNOTES
* Corresponding author: Saito Higuchi, Biological Research Laboratories, Daiichi Sankyo Co., Ltd., 16-13, 1-Chome Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan, Tel: 81-3-5696-3915, Fax: 81-3-5696-4264, higuchi.saito.ir@daiichisankyo.co.jp
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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