tetano
Editor, Senior Moderator
J Infect Dis. 2019 Jan 31. doi: 10.1093/infdis/jiz010. [Epub ahead of print]
[h=1]Antibody Determinants of Influenza Immunity.[/h] Crowe JE Jr[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the antigenic variation in circulating influenza virus strains and how the human immune system recognizes diverse virus strains is one of the central challenges of our time for human vaccinologists. Antibodies directed to the two major integral membrane proteins on the surface of viral particles, hemagglutinin (HA) and neuraminidase (NA), mediate protection against reinfection following natural infection or vaccination, but the HA and NA proteins in field strains are highly variable in sequence. The central questions about influenza immunity today are how to achieve protective antibody responses in a higher proportion of individuals, and how to induce responses with more breadth and more durability. Recent studies using isolation of human monoclonal antibodies followed by structural and functional characterization have revealed conserved antigenic sites that are recognized by broadly cross-reactive antibodies. The antigenic landscape on the HA and NA proteins is coming into focus in a way that informs new studies of the correlates and mechanisms of immunity. Understanding the antibody determinants of influenza immunity points the way toward development and testing of next generation vaccines that have the potential to confer broadly protective immunity.
PMID: 30715373 DOI: 10.1093/infdis/jiz010
[h=1]Antibody Determinants of Influenza Immunity.[/h] Crowe JE Jr[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the antigenic variation in circulating influenza virus strains and how the human immune system recognizes diverse virus strains is one of the central challenges of our time for human vaccinologists. Antibodies directed to the two major integral membrane proteins on the surface of viral particles, hemagglutinin (HA) and neuraminidase (NA), mediate protection against reinfection following natural infection or vaccination, but the HA and NA proteins in field strains are highly variable in sequence. The central questions about influenza immunity today are how to achieve protective antibody responses in a higher proportion of individuals, and how to induce responses with more breadth and more durability. Recent studies using isolation of human monoclonal antibodies followed by structural and functional characterization have revealed conserved antigenic sites that are recognized by broadly cross-reactive antibodies. The antigenic landscape on the HA and NA proteins is coming into focus in a way that informs new studies of the correlates and mechanisms of immunity. Understanding the antibody determinants of influenza immunity points the way toward development and testing of next generation vaccines that have the potential to confer broadly protective immunity.
PMID: 30715373 DOI: 10.1093/infdis/jiz010