tetano
Editor, Senior Moderator
J Virol. 2013 Mar 6. [Epub ahead of print]
Antibody-dependent cellular cytotoxicity (ADCC) is associated with control of pandemic H1N1 influenza virus infection of macaques.
Jegaskanda S, Weinfurter JT, Friedrich TC, Kent SJ.
Source
Department of Microbiology and Immunology, University of Melbourne, Victoria, 3010, Australia.
Abstract
Emerging influenza viruses pose a serious risk to global human health. Recent studies in ferrets, macaques and humans suggest that seasonal H1N1 (sH1N1) infection provides some cross-protection against 2009 pandemic influenza viruses (H1N1pdm) but the correlates of cross-protection are poorly understood. Here we show that seasonal infection of influenza-naive Indian rhesus macaques (Macaca mulatta) with A/Kawasaki/173/2001 (K173; sH1N1) virus induces antibodies capable of binding the haemagglutinin (HA) of both the homologous seasonal virus and the antigenically divergent A/California/04/2009 (CA/04; H1N1pdm) strain, in the absence of detectable H1N1pdm-specific neutralizing antibodies. These influenza-specific antibodies activated macaque NK cells to express both CD107a and IFN-γ in the presence of HA proteins from either sH1N1 or H1N1pdm viruses. Although, influenza-specific ADCC mediated NK cell activation diminished in titre over time following sH1N1 infection, they rapidly expanded within 7 days following H1N1pdm exposure. Further, we found that influenza-specific ADCC was present in broncho-alveolar lavage fluid and able to activate lung NK cells. We conclude that infection with a seasonal influenza virus can induce antibodies that mediate ADCC capable of recognizing divergent influenza virus strains. Cross-reactive ADCC may provide a mechanism to reduce the severity of divergent influenza virus infections.
PMID:
23468501
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23468501
Antibody-dependent cellular cytotoxicity (ADCC) is associated with control of pandemic H1N1 influenza virus infection of macaques.
Jegaskanda S, Weinfurter JT, Friedrich TC, Kent SJ.
Source
Department of Microbiology and Immunology, University of Melbourne, Victoria, 3010, Australia.
Abstract
Emerging influenza viruses pose a serious risk to global human health. Recent studies in ferrets, macaques and humans suggest that seasonal H1N1 (sH1N1) infection provides some cross-protection against 2009 pandemic influenza viruses (H1N1pdm) but the correlates of cross-protection are poorly understood. Here we show that seasonal infection of influenza-naive Indian rhesus macaques (Macaca mulatta) with A/Kawasaki/173/2001 (K173; sH1N1) virus induces antibodies capable of binding the haemagglutinin (HA) of both the homologous seasonal virus and the antigenically divergent A/California/04/2009 (CA/04; H1N1pdm) strain, in the absence of detectable H1N1pdm-specific neutralizing antibodies. These influenza-specific antibodies activated macaque NK cells to express both CD107a and IFN-γ in the presence of HA proteins from either sH1N1 or H1N1pdm viruses. Although, influenza-specific ADCC mediated NK cell activation diminished in titre over time following sH1N1 infection, they rapidly expanded within 7 days following H1N1pdm exposure. Further, we found that influenza-specific ADCC was present in broncho-alveolar lavage fluid and able to activate lung NK cells. We conclude that infection with a seasonal influenza virus can induce antibodies that mediate ADCC capable of recognizing divergent influenza virus strains. Cross-reactive ADCC may provide a mechanism to reduce the severity of divergent influenza virus infections.
PMID:
23468501
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23468501