tetano
Editor, Senior Moderator
J Ethnopharmacol. 2014 May 29. pii: S0378-8741(14)00404-8. doi: 10.1016/j.jep.2014.05.035. [Epub ahead of print]
Anti-influenza virus activity of the ethanolic extract from Peperomia sui.
Yang CH1, Tan DH2, Hsu WL2, Jong TT3, Wen CL4, Hsu SL5, Chang PC6.
Author information
Abstract
BACKGROUND:
Peperomia sui Lin & Lu (P. sui), a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. However, no previous study has explored the activity of P. sui against influenza virus infections. This study was carried out to evaluate the anti-influenza virus activity and the potential virucidal effect of the ethanolic extract of P. sui (PSE).
METHODS:
The anti-H6N1 avian influenza viral activity of PSE against the influenza virus A/Chicken/TW/0518/2011 (H6N1) in chicken fibroblast DF-1 cells was evaluated by cell viability assay, hemagglutination assay, neuraminidase activity assay, indirect immunofluorescence assay and quantitative RT-PCR assay.
RESULTS:
PSE significantly increased the viability of cells that were infected by the H6N1 virus. PSE also suppressed the synthesis of viral nucleoprotein (NP), and inhibited the growth of the virus in DF-1 cells. Further, PSE inhibited the neuraminidase activity of H6N1 virus.
CONCLUSIONS:
The findings of this study provide important information for the exploitation and utilization of P. sui in treatment of influenza infection.
Copyright ? 2014. Published by Elsevier Ireland Ltd.
KEYWORDS:
Antiviral activity; Hemagglutination; Influenza virus; Peperomia sui
PMID:
24882727
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24882727
Anti-influenza virus activity of the ethanolic extract from Peperomia sui.
Yang CH1, Tan DH2, Hsu WL2, Jong TT3, Wen CL4, Hsu SL5, Chang PC6.
Author information
Abstract
BACKGROUND:
Peperomia sui Lin & Lu (P. sui), a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. However, no previous study has explored the activity of P. sui against influenza virus infections. This study was carried out to evaluate the anti-influenza virus activity and the potential virucidal effect of the ethanolic extract of P. sui (PSE).
METHODS:
The anti-H6N1 avian influenza viral activity of PSE against the influenza virus A/Chicken/TW/0518/2011 (H6N1) in chicken fibroblast DF-1 cells was evaluated by cell viability assay, hemagglutination assay, neuraminidase activity assay, indirect immunofluorescence assay and quantitative RT-PCR assay.
RESULTS:
PSE significantly increased the viability of cells that were infected by the H6N1 virus. PSE also suppressed the synthesis of viral nucleoprotein (NP), and inhibited the growth of the virus in DF-1 cells. Further, PSE inhibited the neuraminidase activity of H6N1 virus.
CONCLUSIONS:
The findings of this study provide important information for the exploitation and utilization of P. sui in treatment of influenza infection.
Copyright ? 2014. Published by Elsevier Ireland Ltd.
KEYWORDS:
Antiviral activity; Hemagglutination; Influenza virus; Peperomia sui
PMID:
24882727
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24882727