tetano
Editor, Senior Moderator
Ann Hum Biol
. 2024 Feb;51(1):2341727.
doi: 10.1080/03014460.2024.2341727. Epub 2024 May 21. Increased prevalence of the COVID-19 associated Neanderthal mutations in the Central European Roma population
Jaroslav A Hubáček[SUP] 1 2 [/SUP], Lenka Šedová[SUP] 3 [/SUP], Věra Hellerová[SUP] 3 [/SUP], Věra Adámková[SUP] 4 [/SUP], Valérie Tóthová[SUP] 3 [/SUP]
Affiliations
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent COVID-19 has spread world-wide and become pandemic with about 7 million deaths reported so far. Interethnic variability of the disease has been described, but a significant part of the differences remain unexplained and may be attributable to genetic factors.
Aim: To analyse genetic factors potentially influencing COVID-19 susceptibility and severity in European Roma minority.
Subjects and methods: Two genetic determinants, within OAS-1 (2-prime,5-prime-oligoadenylate synthetase 1, a key protein in the defence against viral infection; it activates RNases that degrade viral RNAs; rs4767027 has been analysed) and LZTFL1 (leucine zipper transcription factor-like 1, expressed in the lung respiratory epithelium; rs35044562 has been analysed) genes were screened in a population-sample of Czech Roma (N = 302) and majority population (N = 2,559).
Results: For both polymorphisms, Roma subjects were more likely carriers of at least one risky allele for both rs4767027-C (p < 0.001) and rs35044562-G (p < 0.00001) polymorphism. There were only 5.3% Roma subjects without at least one risky allele in comparison with 10.1% in the majority population (p < 0.01).
Conclusions: It is possible that different genetic background plays an important role in increased prevalence of COVID-19 in the Roma minority.
Keywords: COVID-19; Roma; ethnicity; polymorphism.
. 2024 Feb;51(1):2341727.
doi: 10.1080/03014460.2024.2341727. Epub 2024 May 21. Increased prevalence of the COVID-19 associated Neanderthal mutations in the Central European Roma population
Jaroslav A Hubáček[SUP] 1 2 [/SUP], Lenka Šedová[SUP] 3 [/SUP], Věra Hellerová[SUP] 3 [/SUP], Věra Adámková[SUP] 4 [/SUP], Valérie Tóthová[SUP] 3 [/SUP]
Affiliations
- PMID: 38771659
- DOI: 10.1080/03014460.2024.2341727
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent COVID-19 has spread world-wide and become pandemic with about 7 million deaths reported so far. Interethnic variability of the disease has been described, but a significant part of the differences remain unexplained and may be attributable to genetic factors.
Aim: To analyse genetic factors potentially influencing COVID-19 susceptibility and severity in European Roma minority.
Subjects and methods: Two genetic determinants, within OAS-1 (2-prime,5-prime-oligoadenylate synthetase 1, a key protein in the defence against viral infection; it activates RNases that degrade viral RNAs; rs4767027 has been analysed) and LZTFL1 (leucine zipper transcription factor-like 1, expressed in the lung respiratory epithelium; rs35044562 has been analysed) genes were screened in a population-sample of Czech Roma (N = 302) and majority population (N = 2,559).
Results: For both polymorphisms, Roma subjects were more likely carriers of at least one risky allele for both rs4767027-C (p < 0.001) and rs35044562-G (p < 0.00001) polymorphism. There were only 5.3% Roma subjects without at least one risky allele in comparison with 10.1% in the majority population (p < 0.01).
Conclusions: It is possible that different genetic background plays an important role in increased prevalence of COVID-19 in the Roma minority.
Keywords: COVID-19; Roma; ethnicity; polymorphism.