tetano
Editor, Senior Moderator
Animals (Basel)
. 2023 Nov 28;13(23):3680.
doi: 10.3390/ani13233680. Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice
Xiaoquan Wang[SUP] 1 2 3 4 [/SUP], Huafen Zheng[SUP] 1 [/SUP], Ruyi Gao[SUP] 1 2 3 [/SUP], Leyao Ren[SUP] 1 [/SUP], Mingxia Jin[SUP] 1 [/SUP], Zhuxing Ji[SUP] 1 [/SUP], Xin Wang[SUP] 1 [/SUP], Xiaolong Lu[SUP] 1 2 3 [/SUP], Wenhao Yang[SUP] 1 2 3 [/SUP], Min Gu[SUP] 1 2 3 [/SUP], Xiaowen Liu[SUP] 1 2 3 [/SUP], Shunlin Hu[SUP] 1 2 3 [/SUP], Kaituo Liu[SUP] 1 2 3 4 [/SUP], Xiufan Liu[SUP] 1 2 3 4 [/SUP]
Affiliations
Avian influenza viruses can cross species barriers and adapt to mammals. The H7N9 subtype AIV that emerged in China in 2013 caused 1568 human infections, with a mortality rate of nearly 40%. We conducted a retrospective analysis of H7N9 viruses that were isolated in live poultry markets in 2013. We found that two avian-origin H7N9 isolates, A/chicken/Eastern China/JTC4/2013 and A/chicken/Eastern China/JTC11/2013, have a similar genetic background but exhibit different pathogenicity in mice. Whole-genome alignment of the two H7N9 viruses was carried out, and only six amino acid differences mapped in five genes, including the well-known virulence molecular marker PB2-E627K. Our retrospective analysis highlighted the importance of monitoring the adaptive mutations in avian influenza viruses with zoonotic potential.
Keywords: H7N9; PB2-E627K; mice; pathogenicity.
. 2023 Nov 28;13(23):3680.
doi: 10.3390/ani13233680. Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice
Xiaoquan Wang[SUP] 1 2 3 4 [/SUP], Huafen Zheng[SUP] 1 [/SUP], Ruyi Gao[SUP] 1 2 3 [/SUP], Leyao Ren[SUP] 1 [/SUP], Mingxia Jin[SUP] 1 [/SUP], Zhuxing Ji[SUP] 1 [/SUP], Xin Wang[SUP] 1 [/SUP], Xiaolong Lu[SUP] 1 2 3 [/SUP], Wenhao Yang[SUP] 1 2 3 [/SUP], Min Gu[SUP] 1 2 3 [/SUP], Xiaowen Liu[SUP] 1 2 3 [/SUP], Shunlin Hu[SUP] 1 2 3 [/SUP], Kaituo Liu[SUP] 1 2 3 4 [/SUP], Xiufan Liu[SUP] 1 2 3 4 [/SUP]
Affiliations
- PMID: 38067031
- PMCID: PMC10705590
- DOI: 10.3390/ani13233680
Avian influenza viruses can cross species barriers and adapt to mammals. The H7N9 subtype AIV that emerged in China in 2013 caused 1568 human infections, with a mortality rate of nearly 40%. We conducted a retrospective analysis of H7N9 viruses that were isolated in live poultry markets in 2013. We found that two avian-origin H7N9 isolates, A/chicken/Eastern China/JTC4/2013 and A/chicken/Eastern China/JTC11/2013, have a similar genetic background but exhibit different pathogenicity in mice. Whole-genome alignment of the two H7N9 viruses was carried out, and only six amino acid differences mapped in five genes, including the well-known virulence molecular marker PB2-E627K. Our retrospective analysis highlighted the importance of monitoring the adaptive mutations in avian influenza viruses with zoonotic potential.
Keywords: H7N9; PB2-E627K; mice; pathogenicity.