animal studies

[gsgs]

we are used to see these with influenza
Fouchier, Tumpey and his ferrets
Palese and his guinea pigs
lots of mice


tests in mice:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528275/
http://www.ncbi.nlm.nih.gov/pubmed/21852521

Rodent models such as mouse, guinea pig, and hamster, have also been developed.
However, these rodent models require adaptation of the virus to produce lethal disease
and do not mirror all symptoms of human filovirus infection
http://www.ncbi.nlm.nih.gov/pubmed/24046765

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[gsgs]

Re: animal studies

foodborne ebola , ebola in pigs :

Ebola Virus as a Foodborne Pathogen? Cause for
Consideration, but Not Panic - 2010

http://jid.oxfordjournals.org/content/204/2/179.full.pdf
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the EBOV lipid envelope renders it relatively unstable in the environment [15].
Infection in persons whose sole contact is with meat procured by others
has not been reported and is probably rare, if it occurs at all,

ebola-Reston: of .800 persons potentially exposed, only 15 (2%) have developed antibody
(including 4 in whom seroconversion was documented),
and none have developed symptoms [9, 12]

in the laboratory, relative to ZEBOV, REBOV exhibits delayed replication and a milder
cytopathogenic effect [17]; a decreased rate of cleavage of the glycoprotein
(considered an important step in virus activation and pathogenicity) [18]; and
less infectivity [19], endothelial cell damage [4], lymphocyte apoptosis [20],
down-regulation of the immune response [21], and antibody-dependent
enhancement [22]. As for ZEBOV and the other known pathogenic EBOVs,
there has been no suspicion of pigs playing a role in any outbreaks to date.

minor sequence changes have sometimes been associated with enhanced
pathogenicity in monkey models

EBOV pathogenicity can be enhanced by serial passage in animals and cell culture [23–25].


In conclusion, the laboratory findings by Kobinger et al [1] combined with the
previous results of field investigations in the Philippines [9] highlight the possi-
bility of EBOV as a foodborne pathogen

1. Kobinger GP, Leung A, Neufeld J, et al. Replication, Pathogenicity, Shedding,
and Transmission of Zaire ebolavirus in Pigs. J Infect Dis 2011; 204:200–8.
9. Barrette RW, Metwally SA, Rowland JM, et al. Discovery of swine as a host for the
Reston ebolavirus. Science 2009; 325:204–6.