tetano
Editor, Senior Moderator
Anaesthesiol Intensive Ther
. 2022;54(1):12-17.
doi: 10.5114/ait.2022.113738.
Predicting the effectiveness of high-flow oxygen therapy in COVID-19 patients: a single-centre observational study
Felicitas Schmidt[SUP] 1 [/SUP], Lorenz Nowak[SUP] 1 [/SUP], Florian Obereisenbuchler[SUP] 2 [/SUP], Justin Hetrodt[SUP] 2 [/SUP], Marion Heiß-Neumann[SUP] 2 [/SUP], Anna Schönlebe[SUP] 1 [/SUP], Katharina Heinig-Menhard[SUP] 1 [/SUP], Wolfgang Gesierich[SUP] 2 [/SUP], Jürgen Behr[SUP] 2 3 4 [/SUP], Rudolf Hatz[SUP] 5 6 [/SUP], Julien Dinkel[SUP] 5 6 7 [/SUP], Mircea-Gabriel Stoleriu[SUP] 4 5 6 [/SUP]
Affiliations
Abstract
Background: High-flow nasal cannula (HFNC) therapy is a helpful tool in the treatment of hypoxaemic respiratory failure. However, the clinical parameters predicting the effectiveness of HFNC in coronavirus-19 disease (COVID-19) patients remain unclear.
Methods: Sixteen COVID-19 patients undergoing HFNC in the Asklepios Lung Clinic Munich-Gauting, Germany between 16 March and 3 June 2020 were retrospectively included into the study. Seven patients successfully recovered after HFNC (Group 1), while 9 patients required intubation upon HFNC failure (Group 2). Relevant predictors for an effective HFNC therapy were analysed on day 0 and 4 after HFNC initiation via receiver operating characteristics.
Results: The groups did not differ significantly in terms of age, sex, body mass index, and comorbidities. Five patients died in Group 2 upon disease progression and HFNC failure. Group 1 required a lower oxygen supplementation (FiO2 0.46 [0.31-0.54] vs. 0.72 [0.54-0.76], P = 0.022) and displayed a higher PaO2/FiO2 ratio (115 [111-201] vs. 93.3 [67.2-145], P = 0.042) on day 0. In Group 2, fever persisted on day 4 (38.5 [38.0-39.4]°C vs. 36.5 [31.1-37.1]°C, P = 0.010). Serum C-reactive protein (CRP) levels > 108 mg L-1 (day 0) and persistent oxygen saturation < 89% and PaO2/FiO2 ratio < 91 (day 4) were identified as significant predictors for HFNC failure (area under curve 0.929, 0.933, and 0.893).
Conclusions: Elevated oxygen saturation, decreased FiO2 and reduced serum CRP on day 4 significantly predict HFNC effectiveness in COVID-19 patients. Based on these parameters, larger prospective studies are necessary to further investigate the effectiveness of HFNC in the treatment of COVID-19-associated hypoxaemic respiratory failure.
Keywords: SARS-CoV-2; high-flow therapy; intensive care; COVID-19.
. 2022;54(1):12-17.
doi: 10.5114/ait.2022.113738.
Predicting the effectiveness of high-flow oxygen therapy in COVID-19 patients: a single-centre observational study
Felicitas Schmidt[SUP] 1 [/SUP], Lorenz Nowak[SUP] 1 [/SUP], Florian Obereisenbuchler[SUP] 2 [/SUP], Justin Hetrodt[SUP] 2 [/SUP], Marion Heiß-Neumann[SUP] 2 [/SUP], Anna Schönlebe[SUP] 1 [/SUP], Katharina Heinig-Menhard[SUP] 1 [/SUP], Wolfgang Gesierich[SUP] 2 [/SUP], Jürgen Behr[SUP] 2 3 4 [/SUP], Rudolf Hatz[SUP] 5 6 [/SUP], Julien Dinkel[SUP] 5 6 7 [/SUP], Mircea-Gabriel Stoleriu[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 35359136
- DOI: 10.5114/ait.2022.113738
Abstract
Background: High-flow nasal cannula (HFNC) therapy is a helpful tool in the treatment of hypoxaemic respiratory failure. However, the clinical parameters predicting the effectiveness of HFNC in coronavirus-19 disease (COVID-19) patients remain unclear.
Methods: Sixteen COVID-19 patients undergoing HFNC in the Asklepios Lung Clinic Munich-Gauting, Germany between 16 March and 3 June 2020 were retrospectively included into the study. Seven patients successfully recovered after HFNC (Group 1), while 9 patients required intubation upon HFNC failure (Group 2). Relevant predictors for an effective HFNC therapy were analysed on day 0 and 4 after HFNC initiation via receiver operating characteristics.
Results: The groups did not differ significantly in terms of age, sex, body mass index, and comorbidities. Five patients died in Group 2 upon disease progression and HFNC failure. Group 1 required a lower oxygen supplementation (FiO2 0.46 [0.31-0.54] vs. 0.72 [0.54-0.76], P = 0.022) and displayed a higher PaO2/FiO2 ratio (115 [111-201] vs. 93.3 [67.2-145], P = 0.042) on day 0. In Group 2, fever persisted on day 4 (38.5 [38.0-39.4]°C vs. 36.5 [31.1-37.1]°C, P = 0.010). Serum C-reactive protein (CRP) levels > 108 mg L-1 (day 0) and persistent oxygen saturation < 89% and PaO2/FiO2 ratio < 91 (day 4) were identified as significant predictors for HFNC failure (area under curve 0.929, 0.933, and 0.893).
Conclusions: Elevated oxygen saturation, decreased FiO2 and reduced serum CRP on day 4 significantly predict HFNC effectiveness in COVID-19 patients. Based on these parameters, larger prospective studies are necessary to further investigate the effectiveness of HFNC in the treatment of COVID-19-associated hypoxaemic respiratory failure.
Keywords: SARS-CoV-2; high-flow therapy; intensive care; COVID-19.