tetano
Editor, Senior Moderator
Vaccine. 2010 Oct 26. [Epub ahead of print]
An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers.
Madhun AS, Akselsen PE, Sjursen H, Pedersen G, Svindland S, N?stbakken JK, Nilsen M, Mohn K, Jul-Larsen A, Smith I, Major D, Wood J, Cox RJ.
Influenza Centre, The Gade Institute, University of Bergen, N-5021 Bergen, Norway.
Abstract
Mass vaccination was the most effective prophylaxis for protecting the population during the influenza H1N1 pandemic. We have evaluated the tolerability, immunogenicity and kinetics of the antibody response to a monovalent oil-in-water (AS03) adjuvanted human pandemic split influenza A/California/7/2009 H1N1 (3.75μg haemagglutinin) vaccine in health care workers. Vaccination elicited a rapid and early protective level of haemagglutination inhibition antibody from 6 to 7 days post vaccination, and by 14 to 21 days post vaccination, up to 98% of vaccinees had protective antibody titres which persisted for at least 3 months in 84-92% of subjects. A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 21034828 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21034828
An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers.
Madhun AS, Akselsen PE, Sjursen H, Pedersen G, Svindland S, N?stbakken JK, Nilsen M, Mohn K, Jul-Larsen A, Smith I, Major D, Wood J, Cox RJ.
Influenza Centre, The Gade Institute, University of Bergen, N-5021 Bergen, Norway.
Abstract
Mass vaccination was the most effective prophylaxis for protecting the population during the influenza H1N1 pandemic. We have evaluated the tolerability, immunogenicity and kinetics of the antibody response to a monovalent oil-in-water (AS03) adjuvanted human pandemic split influenza A/California/7/2009 H1N1 (3.75μg haemagglutinin) vaccine in health care workers. Vaccination elicited a rapid and early protective level of haemagglutination inhibition antibody from 6 to 7 days post vaccination, and by 14 to 21 days post vaccination, up to 98% of vaccinees had protective antibody titres which persisted for at least 3 months in 84-92% of subjects. A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 21034828 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21034828