tetano
Editor, Senior Moderator
Am J Trop Med Hyg. 2020 Apr 17. doi: 10.4269/ajtmh.20-0276. [Epub ahead of print]
Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with Novel Coronavirus Disease (COVID-19).
Falc?o MB[SUP]1[/SUP], Pamplona de G?es Cavalcanti L[SUP]2[/SUP], Filgueiras Filho NM[SUP]3,[/SUP][SUP]4[/SUP], Antunes de Brito CA[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP].
Author information
Abstract
Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases, followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy.
PMID:32314698DOI:10.4269/ajtmh.20-0276
Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with Novel Coronavirus Disease (COVID-19).
Falc?o MB[SUP]1[/SUP], Pamplona de G?es Cavalcanti L[SUP]2[/SUP], Filgueiras Filho NM[SUP]3,[/SUP][SUP]4[/SUP], Antunes de Brito CA[SUP]5,[/SUP][SUP]6,[/SUP][SUP]7[/SUP].
Author information
Abstract
Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases, followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy.
PMID:32314698DOI:10.4269/ajtmh.20-0276