tetano
Editor, Senior Moderator
Am J Trop Med Hyg
. 2022 Feb 25;tpmd210713.
doi: 10.4269/ajtmh.21-0713. Online ahead of print.
Case Report: COVID-19 and Lassa Fever Coinfection in an Ebola Suspected Patient in Guinea
Mory Keita[SUP] 1 2 [/SUP], Mahamoud Sama Cherif[SUP] 3 [/SUP], Billy Sivahera[SUP] 4 [/SUP], Samuel T Boland[SUP] 5 [/SUP], Freddy Banza-Mutoka[SUP] 1 [/SUP], Mamadou Kourouma[SUP] 4 [/SUP], Alseny Modet Camara[SUP] 6 [/SUP], Youssouf Sidibe[SUP] 7 [/SUP], Jean Paul Kimenyi[SUP] 1 [/SUP], Lamine Diassy[SUP] 4 [/SUP], Angelo Loua[SUP] 8 [/SUP], Ibrahima Sory Fofana[SUP] 4 [/SUP], Youba Kandako[SUP] 4 [/SUP], Dobo Onivogui[SUP] 9 [/SUP], Enogo Koivogui[SUP] 10 [/SUP], Tamba Jacques Millimono[SUP] 10 [/SUP], Fode Diakite[SUP] 4 [/SUP], Mamadou Balde[SUP] 4 [/SUP], Bienvenu Houndjo[SUP] 4 [/SUP], Ngoy Nsenga[SUP] 1 [/SUP], Ambrose Talisuna[SUP] 1 [/SUP], Alexandre Delamou[SUP] 3 11 [/SUP], Olivia Keiser[SUP] 2 [/SUP], Georges Alfred Ki-Zerbo[SUP] 4 [/SUP], Abdou Salam Gueye[SUP] 1 [/SUP]
Affiliations
Abstract
In this case report, we describe a clinical presentation and therapeutic history of a unique case diagnosed with Lassa fever and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a 23-year-old man from Yomou prefecture in southeast Guinea identified with suspected Ebola Virus Disease (EVD) in the midst of an ongoing outbreak of that disease in the same region. On May 3, 2021, he was admitted to the Nzérékoré Epidemic disease treatment center where his clinical condition deteriorated significantly. Laboratory testing performed on the same day reveals a negative EVD polymerase chain reaction (PCR). Three days later, the patient was tested positive for SARS-CoV-2 and Lassa fever by reverse transcriptase PCR (RT-PCR) assays. Laboratory examination also indicated severe hematological and biochemical deteriorations in the patient. This case substantiates the need for systematic differential diagnosis during epidemic-prone disease outbreaks to better manage severely unwell patients.
. 2022 Feb 25;tpmd210713.
doi: 10.4269/ajtmh.21-0713. Online ahead of print.
Case Report: COVID-19 and Lassa Fever Coinfection in an Ebola Suspected Patient in Guinea
Mory Keita[SUP] 1 2 [/SUP], Mahamoud Sama Cherif[SUP] 3 [/SUP], Billy Sivahera[SUP] 4 [/SUP], Samuel T Boland[SUP] 5 [/SUP], Freddy Banza-Mutoka[SUP] 1 [/SUP], Mamadou Kourouma[SUP] 4 [/SUP], Alseny Modet Camara[SUP] 6 [/SUP], Youssouf Sidibe[SUP] 7 [/SUP], Jean Paul Kimenyi[SUP] 1 [/SUP], Lamine Diassy[SUP] 4 [/SUP], Angelo Loua[SUP] 8 [/SUP], Ibrahima Sory Fofana[SUP] 4 [/SUP], Youba Kandako[SUP] 4 [/SUP], Dobo Onivogui[SUP] 9 [/SUP], Enogo Koivogui[SUP] 10 [/SUP], Tamba Jacques Millimono[SUP] 10 [/SUP], Fode Diakite[SUP] 4 [/SUP], Mamadou Balde[SUP] 4 [/SUP], Bienvenu Houndjo[SUP] 4 [/SUP], Ngoy Nsenga[SUP] 1 [/SUP], Ambrose Talisuna[SUP] 1 [/SUP], Alexandre Delamou[SUP] 3 11 [/SUP], Olivia Keiser[SUP] 2 [/SUP], Georges Alfred Ki-Zerbo[SUP] 4 [/SUP], Abdou Salam Gueye[SUP] 1 [/SUP]
Affiliations
- PMID: 35213814
- DOI: 10.4269/ajtmh.21-0713
Abstract
In this case report, we describe a clinical presentation and therapeutic history of a unique case diagnosed with Lassa fever and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a 23-year-old man from Yomou prefecture in southeast Guinea identified with suspected Ebola Virus Disease (EVD) in the midst of an ongoing outbreak of that disease in the same region. On May 3, 2021, he was admitted to the Nzérékoré Epidemic disease treatment center where his clinical condition deteriorated significantly. Laboratory testing performed on the same day reveals a negative EVD polymerase chain reaction (PCR). Three days later, the patient was tested positive for SARS-CoV-2 and Lassa fever by reverse transcriptase PCR (RT-PCR) assays. Laboratory examination also indicated severe hematological and biochemical deteriorations in the patient. This case substantiates the need for systematic differential diagnosis during epidemic-prone disease outbreaks to better manage severely unwell patients.