tetano
Editor, Senior Moderator
Am J Transplant
. 2022 Apr 5.
doi: 10.1111/ajt.17055. Online ahead of print.
Effect of influenza vaccination in solid organ transplant recipients: A nationwide population-based cohort study
Zitta Barrella Harboe[SUP] 1 2 3 [/SUP], Daniel Modin[SUP] 4 [/SUP], Finn Gustafsson[SUP] 5 3 [/SUP], Michael Perch[SUP] 5 3 [/SUP], Gunnar Gislason[SUP] 4 3 [/SUP], Søren Schwartz Sørensen[SUP] 6 [/SUP], Allan Rasmussen[SUP] 7 [/SUP], Tor Biering-Sørensen[SUP] 4 8 [/SUP], Susanne Dam Nielsen[SUP] 1 3 [/SUP]
Affiliations
Abstract
Vaccination can prevent influenza in solid organ transplant (SOT) recipients. Using a modified season-specific approach over nine consecutive influenza seasons, we investigated influenza vaccination coverage and effectiveness in a population-based nationwide cohort study that included all SOT recipients aged ≥ 18 years who were living in Denmark from 1 December 2007 to 1 April 2016. The primary outcome was the season-specific risk of all-cause pneumonia admission. Secondary outcomes were season-specific influenza-related admission, intensive care unit (ICU) admission, and all-cause mortality. Crude and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. In total, 11,381 person-years of follow-up data were collected from 5,745 SOT recipients, 48% of whom were vaccinated. Influenza vaccination was associated with a reduced risk of all-cause pneumonia admission (aHR, 0.83; 95% CI, 0.69-0.99; p = 0.035) and all-cause mortality (aHR, 0.60; 95% CI, 0.47-0.76; p = 0.001), but not influenza-related admission (aHR, 0.75; 95% CI, 0.46-1.22; p = 0.24) or ICU admission (aHR, 0.84; 95% CI, 0.67-1.06; p = 0.14) during the same season. Despite these benefits, uptake of influenza vaccination among SOT recipients was low. Therefore, annual influenza vaccination needs to be prioritized.
Keywords: Influenza; SOT; pneumonia; vaccination.
. 2022 Apr 5.
doi: 10.1111/ajt.17055. Online ahead of print.
Effect of influenza vaccination in solid organ transplant recipients: A nationwide population-based cohort study
Zitta Barrella Harboe[SUP] 1 2 3 [/SUP], Daniel Modin[SUP] 4 [/SUP], Finn Gustafsson[SUP] 5 3 [/SUP], Michael Perch[SUP] 5 3 [/SUP], Gunnar Gislason[SUP] 4 3 [/SUP], Søren Schwartz Sørensen[SUP] 6 [/SUP], Allan Rasmussen[SUP] 7 [/SUP], Tor Biering-Sørensen[SUP] 4 8 [/SUP], Susanne Dam Nielsen[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35384275
- DOI: 10.1111/ajt.17055
Abstract
Vaccination can prevent influenza in solid organ transplant (SOT) recipients. Using a modified season-specific approach over nine consecutive influenza seasons, we investigated influenza vaccination coverage and effectiveness in a population-based nationwide cohort study that included all SOT recipients aged ≥ 18 years who were living in Denmark from 1 December 2007 to 1 April 2016. The primary outcome was the season-specific risk of all-cause pneumonia admission. Secondary outcomes were season-specific influenza-related admission, intensive care unit (ICU) admission, and all-cause mortality. Crude and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. In total, 11,381 person-years of follow-up data were collected from 5,745 SOT recipients, 48% of whom were vaccinated. Influenza vaccination was associated with a reduced risk of all-cause pneumonia admission (aHR, 0.83; 95% CI, 0.69-0.99; p = 0.035) and all-cause mortality (aHR, 0.60; 95% CI, 0.47-0.76; p = 0.001), but not influenza-related admission (aHR, 0.75; 95% CI, 0.46-1.22; p = 0.24) or ICU admission (aHR, 0.84; 95% CI, 0.67-1.06; p = 0.14) during the same season. Despite these benefits, uptake of influenza vaccination among SOT recipients was low. Therefore, annual influenza vaccination needs to be prioritized.
Keywords: Influenza; SOT; pneumonia; vaccination.