tetano
Editor, Senior Moderator
Am J Reprod Immunol
. 2024 Nov;92(5):e70012.
doi: 10.1111/aji.70012. Impact of Omicron Variant Infection on Female Fertility and Laboratory Outcomes: A Self-Controlled Study
Yu-Ling Hu[SUP] 1 [/SUP], Yong-Jia Zhang[SUP] 2 3 [/SUP], Xing-Yu Lv[SUP] 1 [/SUP], Rui-Ling Liu[SUP] 3 [/SUP], Zhao-Hui Zhong[SUP] 3 [/SUP], Li-Juan Fu[SUP] 3 4 [/SUP], Mei-Hua Bao[SUP] 4 [/SUP], Li-Hong Geng[SUP] 1 [/SUP], Hai-Jiao Xu[SUP] 1 [/SUP], Shao-Min Yu[SUP] 5 [/SUP], Yu-Bin Ding[SUP] 2 3 [/SUP]
Affiliations
Problem: Investigating the impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection on female fertility and laboratory outcomes in patients undergoing assisted reproductive technology (ART) treatment who were initially uninfected but later became infected.
Methods of the study: This self-controlled study included 197 patients who underwent repeated oocyte retrieval before and after SARS-CoV-2 infection between March 2021 and April 2023, of which 117 used the same ovarian stimulation protocol within a consistent age range. We evaluated the ovarian reserve, ovarian response, and laboratory outcomes in patients before and after SARS-CoV-2 infection.
Results: The ovarian reserve (follicle-stimulating hormone [FSH], luteinizing hormone [LH], estrogen [E[SUB]2[/SUB]], anti-Müllerian hormone [AMH], antral follicle count [AFC]), ovarian response (total Gn dosage, duration of Gn administration, number of follicles ≥14 mm on trigger day, number of retrieved oocytes), and laboratory outcomes (cleavage stage good-quality embryo rate, blastocyst formation rate, and cycle freezing rate) showed no significant differences before and after SARS-CoV-2 infection in 117 patients (p > 0.05). When stratified by age, the ≤ 35 years group showed a higher two pronuclei (2PN) fertilization rate post-infection, while the >35 years group had increased mature metaphase II (MII) oocyte and blastocyst stage good-quality embryo rates. Additionally, upon stratified by the time interval between SARS-CoV-2 infection and ART treatment, in the ≤ 3 months group, there was an increased post-infection MII oocyte rate, 2PN fertilization rate, and blastocyst stage good-quality embryo rate. Meanwhile, no significant differences were found in any indicators when the interval exceeded three months.
Conclusion: Our study suggested that undergoing IVF/ICSI treatment after recovering from COVID-19 may not adversely affect female fertility and laboratory outcomes.
Keywords: COVID‐19; embryo quality; in vitro fertilization; ovarian response.
. 2024 Nov;92(5):e70012.
doi: 10.1111/aji.70012. Impact of Omicron Variant Infection on Female Fertility and Laboratory Outcomes: A Self-Controlled Study
Yu-Ling Hu[SUP] 1 [/SUP], Yong-Jia Zhang[SUP] 2 3 [/SUP], Xing-Yu Lv[SUP] 1 [/SUP], Rui-Ling Liu[SUP] 3 [/SUP], Zhao-Hui Zhong[SUP] 3 [/SUP], Li-Juan Fu[SUP] 3 4 [/SUP], Mei-Hua Bao[SUP] 4 [/SUP], Li-Hong Geng[SUP] 1 [/SUP], Hai-Jiao Xu[SUP] 1 [/SUP], Shao-Min Yu[SUP] 5 [/SUP], Yu-Bin Ding[SUP] 2 3 [/SUP]
Affiliations
- PMID: 39535337
- DOI: 10.1111/aji.70012
Problem: Investigating the impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection on female fertility and laboratory outcomes in patients undergoing assisted reproductive technology (ART) treatment who were initially uninfected but later became infected.
Methods of the study: This self-controlled study included 197 patients who underwent repeated oocyte retrieval before and after SARS-CoV-2 infection between March 2021 and April 2023, of which 117 used the same ovarian stimulation protocol within a consistent age range. We evaluated the ovarian reserve, ovarian response, and laboratory outcomes in patients before and after SARS-CoV-2 infection.
Results: The ovarian reserve (follicle-stimulating hormone [FSH], luteinizing hormone [LH], estrogen [E[SUB]2[/SUB]], anti-Müllerian hormone [AMH], antral follicle count [AFC]), ovarian response (total Gn dosage, duration of Gn administration, number of follicles ≥14 mm on trigger day, number of retrieved oocytes), and laboratory outcomes (cleavage stage good-quality embryo rate, blastocyst formation rate, and cycle freezing rate) showed no significant differences before and after SARS-CoV-2 infection in 117 patients (p > 0.05). When stratified by age, the ≤ 35 years group showed a higher two pronuclei (2PN) fertilization rate post-infection, while the >35 years group had increased mature metaphase II (MII) oocyte and blastocyst stage good-quality embryo rates. Additionally, upon stratified by the time interval between SARS-CoV-2 infection and ART treatment, in the ≤ 3 months group, there was an increased post-infection MII oocyte rate, 2PN fertilization rate, and blastocyst stage good-quality embryo rate. Meanwhile, no significant differences were found in any indicators when the interval exceeded three months.
Conclusion: Our study suggested that undergoing IVF/ICSI treatment after recovering from COVID-19 may not adversely affect female fertility and laboratory outcomes.
Keywords: COVID‐19; embryo quality; in vitro fertilization; ovarian response.