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Am J Physiol Lung Cell Mol Physiol
. 2020 May 20.
doi: 10.1152/ajplung.00153.2020. Online ahead of print.
Estrogen Regulates the Expression of SARS-CoV-2 Receptor ACE2 in Differentiated Airway Epithelial Cells
Kimberly E Stelzig[SUP] 1 [/SUP], Fabrizio Canepa-Escaro[SUP] 2 [/SUP], Marta Schiliro[SUP] 1 [/SUP], Sergejs Berdnikovs[SUP] 3 [/SUP], Y S Prakash[SUP] 1 [/SUP], Sergio E Chiarella[SUP] 4 [/SUP]
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Abstract
There is marked sexual dimorphism in the current COVID-19 pandemic. Here we report that estrogen can regulate the expression of ACE2, a key component for SARS-CoV-2 cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.
Keywords: COVID-19; SARS-CoV-2; coronavirus; epithelial; estrogen.
Favorites
Share
Am J Physiol Lung Cell Mol Physiol
. 2020 May 20.
doi: 10.1152/ajplung.00153.2020. Online ahead of print.
Estrogen Regulates the Expression of SARS-CoV-2 Receptor ACE2 in Differentiated Airway Epithelial Cells
Kimberly E Stelzig[SUP] 1 [/SUP], Fabrizio Canepa-Escaro[SUP] 2 [/SUP], Marta Schiliro[SUP] 1 [/SUP], Sergejs Berdnikovs[SUP] 3 [/SUP], Y S Prakash[SUP] 1 [/SUP], Sergio E Chiarella[SUP] 4 [/SUP]
Affiliations
- PMID: 32432918
- DOI: 10.1152/ajplung.00153.2020
Abstract
There is marked sexual dimorphism in the current COVID-19 pandemic. Here we report that estrogen can regulate the expression of ACE2, a key component for SARS-CoV-2 cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.
Keywords: COVID-19; SARS-CoV-2; coronavirus; epithelial; estrogen.