tetano
Editor, Senior Moderator
Am J Perinatol. 2020 Apr 18. doi: 10.1055/s-0040-1710050. [Epub ahead of print]
Severe COVID-19 during Pregnancy and Possible Vertical Transmission.
Alzamora MC[SUP]1[/SUP], Paredes T[SUP]2[/SUP], Caceres D[SUP]3[/SUP], Webb CM[SUP]4,[/SUP][SUP]5[/SUP], Valdez LM[SUP]5,[/SUP][SUP]6[/SUP], La Rosa M[SUP]1,[/SUP][SUP]7[/SUP].
Author information
Abstract
There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: ? We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. ? This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. ? There were no detectable maternal antibodies for COVID-19 until after delivery..
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
PMID:32305046DOI:10.1055/s-0040-1710050
Severe COVID-19 during Pregnancy and Possible Vertical Transmission.
Alzamora MC[SUP]1[/SUP], Paredes T[SUP]2[/SUP], Caceres D[SUP]3[/SUP], Webb CM[SUP]4,[/SUP][SUP]5[/SUP], Valdez LM[SUP]5,[/SUP][SUP]6[/SUP], La Rosa M[SUP]1,[/SUP][SUP]7[/SUP].
Author information
Abstract
There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: ? We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. ? This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. ? There were no detectable maternal antibodies for COVID-19 until after delivery..
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
PMID:32305046DOI:10.1055/s-0040-1710050