tetano
Editor, Senior Moderator
Am J Hematol
. 2022 Jan 26.
doi: 10.1002/ajh.26478. Online ahead of print.
COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study
Chor-Wing Sing[SUP] 1 [/SUP], Casey Tse Lam Tang[SUP] 1 [/SUP], Celine Sze Ling Chui[SUP] 2 3 4 [/SUP], Min Fan[SUP] 5 [/SUP], Francisco Tsz Tsun Lai[SUP] 4 5 [/SUP], Xue Li[SUP] 4 5 6 [/SUP], Eric Yuk Fai Wan[SUP] 4 5 7 [/SUP], Carlos King Ho Wong[SUP] 4 5 7 [/SUP], Esther Wai Yin Chan[SUP] 4 5 [/SUP], Ivan Fan Ngai Hung[SUP] 6 8 [/SUP], Anskar Yu-Hung Leung[SUP] 9 [/SUP], Ching-Lung Cheung[SUP] 3 4 [/SUP], Ian Chi Kei Wong[SUP] 4 5 10 8 [/SUP]
Affiliations
Abstract
Background: Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID-19). We evaluated the association between COVID-19 vaccines (CoronaVac and BNT162b2) and hematological abnormalities.
Methods: We conducted nested case-control and self-controlled case series (SCCS) analyses using the data from the Hong Kong Hospital Authority and the Department of Health, HKSAR. Outcomes of interest were thrombocytopenia, leukopenia, and neutropenia. Adjusted odds ratios (aORs), incidence rate ratios (IRRs), and 95% confidence intervals (CIs) were estimated using conditional logistic regression.
Results: In total, 1,643,419 people received COVID-19 vaccination (738,609 CoronaVac; 904,810 BNT162b2). We identified 457 and 422 cases after CoronaVac and BNT162b2 vaccination, respectively. For CoronaVac, the incidence of thrombocytopenia, leukopenia, and neutropenia was 2.51, 1.08, 0.15 per 10,000 doses. For BNT162b2, the corresponding incidence were 1.39, 1.17, 0.26 per 10,000 doses. The incidence per 10,000 COVID-19 cases were 1,254, 2,341, and 884, respectively. We only observed an increased risk of leukopenia following the second dose of BNT162b2 (aOR 1.58, 95% CI 1.24 - 2.02; day0-14, IRR 2.21; 95% CI 1.59-3.08). There was no increased risk of any hematological abnormalities after CoronaVac vaccination.
Conclusion: We observed an increased risk of leukopenia shortly after the second dose of BNT162b2. However, the incidence was much lower than the incidence following SARS-COV-2 infections. There was no association between CoronaVac and hematological abnormalities. The benefits of vaccination against COVID-19 still outweigh the risk of hematological abnormalities. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; hematology; leukopenia; neutropenia; thrombocytopenia; vaccination.
. 2022 Jan 26.
doi: 10.1002/ajh.26478. Online ahead of print.
COVID-19 vaccines and risks of hematological abnormalities: nested case-control and self-controlled case series study
Chor-Wing Sing[SUP] 1 [/SUP], Casey Tse Lam Tang[SUP] 1 [/SUP], Celine Sze Ling Chui[SUP] 2 3 4 [/SUP], Min Fan[SUP] 5 [/SUP], Francisco Tsz Tsun Lai[SUP] 4 5 [/SUP], Xue Li[SUP] 4 5 6 [/SUP], Eric Yuk Fai Wan[SUP] 4 5 7 [/SUP], Carlos King Ho Wong[SUP] 4 5 7 [/SUP], Esther Wai Yin Chan[SUP] 4 5 [/SUP], Ivan Fan Ngai Hung[SUP] 6 8 [/SUP], Anskar Yu-Hung Leung[SUP] 9 [/SUP], Ching-Lung Cheung[SUP] 3 4 [/SUP], Ian Chi Kei Wong[SUP] 4 5 10 8 [/SUP]
Affiliations
- PMID: 35080247
- DOI: 10.1002/ajh.26478
Abstract
Background: Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID-19). We evaluated the association between COVID-19 vaccines (CoronaVac and BNT162b2) and hematological abnormalities.
Methods: We conducted nested case-control and self-controlled case series (SCCS) analyses using the data from the Hong Kong Hospital Authority and the Department of Health, HKSAR. Outcomes of interest were thrombocytopenia, leukopenia, and neutropenia. Adjusted odds ratios (aORs), incidence rate ratios (IRRs), and 95% confidence intervals (CIs) were estimated using conditional logistic regression.
Results: In total, 1,643,419 people received COVID-19 vaccination (738,609 CoronaVac; 904,810 BNT162b2). We identified 457 and 422 cases after CoronaVac and BNT162b2 vaccination, respectively. For CoronaVac, the incidence of thrombocytopenia, leukopenia, and neutropenia was 2.51, 1.08, 0.15 per 10,000 doses. For BNT162b2, the corresponding incidence were 1.39, 1.17, 0.26 per 10,000 doses. The incidence per 10,000 COVID-19 cases were 1,254, 2,341, and 884, respectively. We only observed an increased risk of leukopenia following the second dose of BNT162b2 (aOR 1.58, 95% CI 1.24 - 2.02; day0-14, IRR 2.21; 95% CI 1.59-3.08). There was no increased risk of any hematological abnormalities after CoronaVac vaccination.
Conclusion: We observed an increased risk of leukopenia shortly after the second dose of BNT162b2. However, the incidence was much lower than the incidence following SARS-COV-2 infections. There was no association between CoronaVac and hematological abnormalities. The benefits of vaccination against COVID-19 still outweigh the risk of hematological abnormalities. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; hematology; leukopenia; neutropenia; thrombocytopenia; vaccination.