tetano
Editor, Senior Moderator
Am J Emerg Med
. 2020 Sep 30;S0735-6757(20)30868-8.
doi: 10.1016/j.ajem.2020.09.072. Online ahead of print.
SARS-CoV-2 infection and its association with thrombosis and ischemic stroke: a review
Jonathan Snell[SUP] 1 [/SUP]
Affiliations
Abstract
This review of current literature provides background to the COVID-19 pandemic, as well as an examination of potential pathophysiologic mechanisms behind development of thrombosis and ischemic stroke related to COVID-19. SARS-CoV-2 infection is well-documented to cause severe pneumonia, however, thrombosis and thrombotic complications, such as ischemic stroke, have also been documented in a variety of patient demographics. SARS-CoV-2 infection is known to cause a significant inflammatory response, as well as invasion of vascular endothelial cells, resulting in endothelial dysfunction. These factors, coupled with imbalance of ACE2 and RAS axis interactions, have been shown to create a prothrombotic environment, favoring thromboembolic events. Ischemic stroke is a severe complication of COVID-19 and may be a presenting symptom in some patients.
Keywords: COVID-19; Coronavirus; Stroke; Thrombosis.
. 2020 Sep 30;S0735-6757(20)30868-8.
doi: 10.1016/j.ajem.2020.09.072. Online ahead of print.
SARS-CoV-2 infection and its association with thrombosis and ischemic stroke: a review
Jonathan Snell[SUP] 1 [/SUP]
Affiliations
- PMID: 33036853
- DOI: 10.1016/j.ajem.2020.09.072
Abstract
This review of current literature provides background to the COVID-19 pandemic, as well as an examination of potential pathophysiologic mechanisms behind development of thrombosis and ischemic stroke related to COVID-19. SARS-CoV-2 infection is well-documented to cause severe pneumonia, however, thrombosis and thrombotic complications, such as ischemic stroke, have also been documented in a variety of patient demographics. SARS-CoV-2 infection is known to cause a significant inflammatory response, as well as invasion of vascular endothelial cells, resulting in endothelial dysfunction. These factors, coupled with imbalance of ACE2 and RAS axis interactions, have been shown to create a prothrombotic environment, favoring thromboembolic events. Ischemic stroke is a severe complication of COVID-19 and may be a presenting symptom in some patients.
Keywords: COVID-19; Coronavirus; Stroke; Thrombosis.