tetano
Editor, Senior Moderator
Allergy
. 2020 Jun 14.
doi: 10.1111/all.14449. Online ahead of print.
A Compendium Answering 150 Questions on COVID-19 and SARS-CoV-2
Carmen Riggioni[SUP] 1 2 [/SUP], Pasquale Comberiati[SUP] 3 4 [/SUP], Mattia Giovannini[SUP] 5 [/SUP], Ioana Agache[SUP] 6 [/SUP], M?beccel Akdis[SUP] 7 [/SUP], Magna Alves-Correia[SUP] 8 [/SUP], Josep M Ant?[SUP] 9 10 11 12 [/SUP], Alessandra Arcolaci[SUP] 13 [/SUP], Ahmet Kursat Azkur[SUP] 14 [/SUP], Dilek Azkur[SUP] 15 [/SUP], Burcin Beken[SUP] 16 [/SUP], Cristina Boccabella[SUP] 17 [/SUP], Jean Bousquet[SUP] 18 19 [/SUP], Heimo Breiteneder[SUP] 20 [/SUP], Daniela Carvalho[SUP] 21 [/SUP], Leticia De Las Vecillas[SUP] 22 [/SUP], Zuzana Diamant[SUP] 23 24 25 [/SUP], Ibon Eguiluz-Gracia[SUP] 26 [/SUP], Thomas Eiwegger[SUP] 27 28 29 [/SUP], Stefanie Eyerich[SUP] 30 [/SUP], Wytske Fokkens[SUP] 31 [/SUP], Ya-Dong Gao[SUP] 32 [/SUP], Farah Hannachi[SUP] 33 [/SUP], Sebastian L Johnston[SUP] 34 [/SUP], Marek Jutel[SUP] 35 36 [/SUP], Aspasia Karavelia[SUP] 37 [/SUP], Ludger Klimek[SUP] 38 [/SUP], Beatriz Moya[SUP] 39 [/SUP], Kari Nadeau[SUP] 40 [/SUP], Robyn O'Hehir[SUP] 41 42 [/SUP], Liam O'Mahony[SUP] 43 [/SUP], Oliver Pfaar[SUP] 44 [/SUP], Marek Sanak[SUP] 45 [/SUP], J?rgen Schwarze[SUP] 46 [/SUP], Milena Sokolowska[SUP] 7 47 [/SUP], Mar?a J Torres[SUP] 26 [/SUP], Willem van de Veen[SUP] 7 47 [/SUP], Menno C van Zelm[SUP] 41 42 [/SUP], De Yun Wang[SUP] 48 [/SUP], Luo Zhang[SUP] 49 [/SUP], Rodrigo Jim?nez-Saiz[SUP] 50 51 52 [/SUP], Cezmi A Akdis[SUP] 7 [/SUP]
Affiliations
Abstract
In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socio-economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
Keywords: COVID-19; SARS-CoV-2; allergen immunotherapy; allergy; asthma; coronavirus disease 2019; cytokine storm syndrome; epidemiology; pandemic; prevention; severe acute respiratory syndrome-related coronavirus 2.
. 2020 Jun 14.
doi: 10.1111/all.14449. Online ahead of print.
A Compendium Answering 150 Questions on COVID-19 and SARS-CoV-2
Carmen Riggioni[SUP] 1 2 [/SUP], Pasquale Comberiati[SUP] 3 4 [/SUP], Mattia Giovannini[SUP] 5 [/SUP], Ioana Agache[SUP] 6 [/SUP], M?beccel Akdis[SUP] 7 [/SUP], Magna Alves-Correia[SUP] 8 [/SUP], Josep M Ant?[SUP] 9 10 11 12 [/SUP], Alessandra Arcolaci[SUP] 13 [/SUP], Ahmet Kursat Azkur[SUP] 14 [/SUP], Dilek Azkur[SUP] 15 [/SUP], Burcin Beken[SUP] 16 [/SUP], Cristina Boccabella[SUP] 17 [/SUP], Jean Bousquet[SUP] 18 19 [/SUP], Heimo Breiteneder[SUP] 20 [/SUP], Daniela Carvalho[SUP] 21 [/SUP], Leticia De Las Vecillas[SUP] 22 [/SUP], Zuzana Diamant[SUP] 23 24 25 [/SUP], Ibon Eguiluz-Gracia[SUP] 26 [/SUP], Thomas Eiwegger[SUP] 27 28 29 [/SUP], Stefanie Eyerich[SUP] 30 [/SUP], Wytske Fokkens[SUP] 31 [/SUP], Ya-Dong Gao[SUP] 32 [/SUP], Farah Hannachi[SUP] 33 [/SUP], Sebastian L Johnston[SUP] 34 [/SUP], Marek Jutel[SUP] 35 36 [/SUP], Aspasia Karavelia[SUP] 37 [/SUP], Ludger Klimek[SUP] 38 [/SUP], Beatriz Moya[SUP] 39 [/SUP], Kari Nadeau[SUP] 40 [/SUP], Robyn O'Hehir[SUP] 41 42 [/SUP], Liam O'Mahony[SUP] 43 [/SUP], Oliver Pfaar[SUP] 44 [/SUP], Marek Sanak[SUP] 45 [/SUP], J?rgen Schwarze[SUP] 46 [/SUP], Milena Sokolowska[SUP] 7 47 [/SUP], Mar?a J Torres[SUP] 26 [/SUP], Willem van de Veen[SUP] 7 47 [/SUP], Menno C van Zelm[SUP] 41 42 [/SUP], De Yun Wang[SUP] 48 [/SUP], Luo Zhang[SUP] 49 [/SUP], Rodrigo Jim?nez-Saiz[SUP] 50 51 52 [/SUP], Cezmi A Akdis[SUP] 7 [/SUP]
Affiliations
- PMID: 32535955
- DOI: 10.1111/all.14449
Abstract
In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socio-economic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. Over 140 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
Keywords: COVID-19; SARS-CoV-2; allergen immunotherapy; allergy; asthma; coronavirus disease 2019; cytokine storm syndrome; epidemiology; pandemic; prevention; severe acute respiratory syndrome-related coronavirus 2.